Centre for Clinical Brain Sciences
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Research at CCBS is multi-disciplinary, spanning a wide spectrum of methodologies from molecular analyses through human stem cell biology to neuroimaging and clinical trials.
Sub-communities within this community
Collections in this community
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Centre for Clinical Brain Sciences Collection
General collection for Centre for Clinical Brain Sciences (CCBS) -
Derived Data from ADNI (Alzheimer’s Disease Neuroimaging Initiative)
Research using derived data from the ADNI -
Digital Brain Atlases
Brain atlases for assessing different markers of cerebral small vessel disease -
LINCHPIN (Lothian IntraCerebral Haemorrhage, Pathology, Imaging and Neurological Outcome) data
This collection contains data from a clinico-radio-pathological case control study of the causes of intracerebral haemorrhage, based on a community-based inception cohort study in Lothian. -
Potentially serious incidental findings
Data for projects on the epidemiology and impact on participants and health services of potentially serious incidental findings on brain and body magnetic resonance imaging -
REstart or STop Antithrombotics Randomised Trial
RESTART clinical trial -
Search Strategies
Search method protocols and search strategies
Recent Submissions
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Magnetisation transfer saturation (MTsat) processing
MATLAB processing script and functions for MTsat and MTR parametric maps with example dataset and processed output. -
Associations between alcohol use and accelerated biological ageing
Data supporting the manuscript "Associations between alcohol use and accelerated biological ageing". Specifically: Genome Wide Association Study of brain age. -
Epilepsy-related mortality during the COVID-19 pandemic: a nationwide study of routine Scottish data
Methods: This was a national, population-based, cross-sectional study of routinely-collected mortality and demographic data pertaining to March–August of 2020 (COVID-19 pandemic) compared to the corresponding periods in ... -
Search strategies for retrieval of references for effective interventions to support the resilience and mental health of frontline health and social care staff during a global health crisis and following de-escalation
These searches were designed constructed between April and May 2020 to support a series of evidence reviews designed to retrieve all potential references for interventions or management strategies to support the resilience ... -
Search strategies designed to retrieve all references on coronavirus (COVID-19) and stroke healthcare
These search strategies were designed and constructed between May and July 2020. They are designed to retrieve all potential references in stroke healthcare and medicine (including transient ischaemic attack, cerebral small ... -
Systematic review on the variability of the human brain arterial territories assessed using neuroimaging methods
Imaging methods for brain arterial territories have evolved significantly from cadaver injection techniques to combinations of CT angiography with multiple MRI perfusion techniques. The variability of the brain arterial ... -
Search strategy for retrieval of references on stroke healthcare in MEDLINE Ovid
Constructed using the MEDLINE Ovid platform between January and May 2020, this search strategy is designed to retrieve all potential references in stroke healthcare and medicine (including transient ischaemic attack, ... -
RESTART data request form
To request access to the RESTART dataset, please fill out the data request form. Associated documentation is available in the other datasets belonging to this collection, see https://datashare.is.ed.ac.uk/handle/10283/3265 ... -
SUPERSEDED - Search strategy for retrieval of references on stroke healthcare in MEDLINE Ovid
## This dataset has been replaced by the one which can be found at https://doi.org/10.7488/ds/2862 .## Constructed using the MEDLINE Ovid platform between January and May 2020, this search strategy is designed to retrieve ... -
RESTART Data Sharing
Documentation addressing the following aspects of data sharing in relation to the RESTART clinical trial results: * overview and data sharing agreement; * process; * anonymisation; * risk of reidentification; * ... -
Real-world Independent Testing of e-ASPECTS Software (RITeS): Checklist for Statistical Analysis Plan
Statistical Analysis Plan reporting checklist as per: https://www.equator-network.org/reporting-guidelines/guidelines-for-the-content-of-statistical-analysis-plans-in-clinical-trials/ . ## Background - RITeS project ## ... -
Mouse Lifespan Synaptome Atlas dataset
How synapses change molecularly during the lifespan and across all brain circuits is unknown. We analyzed the protein composition of billions of individual synapses from birth to old age on a brain-wide scale in the mouse, ... -
Proteomic analysis of postsynaptic proteins in regions of the human neocortex
The postsynaptic proteome of excitatory synapses comprises ~1,000 highly conserved proteins that control the behavioral repertoire and mutations disrupting their function cause >130 brain diseases. Here, we document the ... -
Methods to quantify and visualize venules using structural magnetic resonance imaging scans
These data were part of a project to design and validate a clinically relevant method to visually assess venules from magnetic resonance imaging (MRI) structural scans, conducted primarily by Miss. Angela C.C. Jochems, ... -
Data for "A smartphone-based test for the assessment of attention deficits in delirium: a case-control diagnostic test accuracy study in older hospitalised patients."
Paper: A smartphone-based test for the assessment of attention deficits in delirium: a case-control diagnostic test accuracy study in older hospitalised patients. ABSTRACT ## Background ## Delirium is a common ... -
SUPERSEDED - Synaptome data with individual synapse parameters, types and subtypes for 10 representative sagittal mouse brain sections across the lifespan
## This item has been replaced by the one which can be found at https://doi.org/10.7488/ds/2796 ## How synapses change molecularly during the lifespan and across all brain circuits is unknown. We analyzed the protein ... -
GWAS summary stats for meta-analysis of epigenetic age acceleration - Gibson et al, (2019)
'Epigenetic age acceleration' is a valuable biomarker of ageing, predictive of morbidity and mortality, but for which the underlying biological mechanisms are not well established. Two commonly used measures, derived from ... -
Supplemental materials for a systematic review of stereotactic radiosurgery for cerebral cavernous malformations
Supplementary data in support of manuscript: "Stereotactic radiosurgery for cerebral cavernous malformations: a systematic review". -
Factors associated with sharing email information and mental health survey participation in large population cohorts
Genome-wide association study summary statistics of email contact and Mental Health Questionnaire participation in UK Biobank. Data in support of the manuscript: "Factors associated with sharing email information and ... -
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