Centre for Clinical Brain Sciences
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Research at CCBS is multi-disciplinary, spanning a wide spectrum of methodologies from molecular analyses through human stem cell biology to neuroimaging and clinical trials.
Sub-communities within this community
Collections in this community
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Centre for Clinical Brain Sciences Collection
General collection for Centre for Clinical Brain Sciences (CCBS) -
Derived Data from ADNI (Alzheimer’s Disease Neuroimaging Initiative)
Research using derived data from the ADNI -
Digital Brain Atlases
Brain atlases for assessing different markers of cerebral small vessel disease -
LINCHPIN (Lothian IntraCerebral Haemorrhage, Pathology, Imaging and Neurological Outcome) data
This collection contains data from a clinico-radio-pathological case control study of the causes of intracerebral haemorrhage, based on a community-based inception cohort study in Lothian. -
Potentially serious incidental findings
Data for projects on the epidemiology and impact on participants and health services of potentially serious incidental findings on brain and body magnetic resonance imaging -
REstart or STop Antithrombotics Randomised Trial
RESTART clinical trial -
Search Strategies
Search method protocols and search strategies
Recent Submissions
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Systematic review of signal post-processing methods in blood-brain barrier dysfunction assessments via dynamic-contrast enhanced magnetic resonance imaging
DCE-MRI enables quantification of vascular permeability, but current acquisition and processing protocols may be sub-optimal. While the literature has started to recognise this is indeed a problem, decisions concerning the ... -
Systematic Review and Meta-Analysis on the Impact of Polycyclic Aromatic Hydrocarbons Exposure in Cognitive Function and Neurodegeneration in Humans
Exposure to air pollution is now recognized globally by governments, leading research scientists, and civil society as one of the greatest public health hazards of the 21st century. Polycyclic aromatic hydrocarbons (PAH) ... -
Human Brain Atlases across the lifespan – Anatomical Segmentations
Dickie and colleagues generated seven age-specific brain tissue sets/atlases of T1-weighted brain MRI illustrative of the adult lifespan from 25 to 92 years, which are representative of the atrophy and neurovascular health ... -
Magnetisation transfer saturation (MTsat) processing
MATLAB processing script and functions for MTsat and MTR parametric maps with example dataset and processed output. -
Associations between alcohol use and accelerated biological ageing
Data supporting the manuscript "Associations between alcohol use and accelerated biological ageing". Specifically: Genome Wide Association Study of brain age. -
Epilepsy-related mortality during the COVID-19 pandemic: a nationwide study of routine Scottish data
Methods: This was a national, population-based, cross-sectional study of routinely-collected mortality and demographic data pertaining to March–August of 2020 (COVID-19 pandemic) compared to the corresponding periods in ... -
Search strategies for retrieval of references for effective interventions to support the resilience and mental health of frontline health and social care staff during a global health crisis and following de-escalation
These searches were designed constructed between April and May 2020 to support a series of evidence reviews designed to retrieve all potential references for interventions or management strategies to support the resilience ... -
Search strategies designed to retrieve all references on coronavirus (COVID-19) and stroke healthcare
These search strategies were designed and constructed between May and July 2020. They are designed to retrieve all potential references in stroke healthcare and medicine (including transient ischaemic attack, cerebral small ... -
Systematic review on the variability of the human brain arterial territories assessed using neuroimaging methods
Imaging methods for brain arterial territories have evolved significantly from cadaver injection techniques to combinations of CT angiography with multiple MRI perfusion techniques. The variability of the brain arterial ... -
Search strategy for retrieval of references on stroke healthcare in MEDLINE Ovid
Constructed using the MEDLINE Ovid platform between January and May 2020, this search strategy is designed to retrieve all potential references in stroke healthcare and medicine (including transient ischaemic attack, ... -
RESTART data request form
To request access to the RESTART dataset, please fill out the data request form. Associated documentation is available in the other datasets belonging to this collection, see https://datashare.is.ed.ac.uk/handle/10283/3265 ... -
SUPERSEDED - Search strategy for retrieval of references on stroke healthcare in MEDLINE Ovid
## This dataset has been replaced by the one which can be found at https://doi.org/10.7488/ds/2862 .## Constructed using the MEDLINE Ovid platform between January and May 2020, this search strategy is designed to retrieve ... -
RESTART Data Sharing
Documentation addressing the following aspects of data sharing in relation to the RESTART clinical trial results: * overview and data sharing agreement; * process; * anonymisation; * risk of reidentification; * ... -
Real-world Independent Testing of e-ASPECTS Software (RITeS): Checklist for Statistical Analysis Plan
Statistical Analysis Plan reporting checklist as per: https://www.equator-network.org/reporting-guidelines/guidelines-for-the-content-of-statistical-analysis-plans-in-clinical-trials/ . ## Background - RITeS project ## ... -
Mouse Lifespan Synaptome Atlas dataset
How synapses change molecularly during the lifespan and across all brain circuits is unknown. We analyzed the protein composition of billions of individual synapses from birth to old age on a brain-wide scale in the mouse, ... -
Proteomic analysis of postsynaptic proteins in regions of the human neocortex
The postsynaptic proteome of excitatory synapses comprises ~1,000 highly conserved proteins that control the behavioral repertoire and mutations disrupting their function cause >130 brain diseases. Here, we document the ... -
Methods to quantify and visualize venules using structural magnetic resonance imaging scans
These data were part of a project to design and validate a clinically relevant method to visually assess venules from magnetic resonance imaging (MRI) structural scans, conducted primarily by Miss. Angela C.C. Jochems, ... -
Data for "A smartphone-based test for the assessment of attention deficits in delirium: a case-control diagnostic test accuracy study in older hospitalised patients."
Paper: A smartphone-based test for the assessment of attention deficits in delirium: a case-control diagnostic test accuracy study in older hospitalised patients. ABSTRACT ## Background ## Delirium is a common ... -
Systematic Review of the Literature on Definitions and Characterisation of MS Lesions
While inspecting the brain magnetic resonance imaging (MRI) scans from a sample of Multiple Sclerosis (MS) patients, blind to any clinical, cognitive and demographic information, it caught our attention the presence of ... -
SUPERSEDED - Synaptome data with individual synapse parameters, types and subtypes for 10 representative sagittal mouse brain sections across the lifespan
## This item has been replaced by the one which can be found at https://doi.org/10.7488/ds/2796 ## How synapses change molecularly during the lifespan and across all brain circuits is unknown. We analyzed the protein ...
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