Centre for Clinical Brain Sciences
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Research at CCBS is multi-disciplinary, spanning a wide spectrum of methodologies from molecular analyses through human stem cell biology to neuroimaging and clinical trials.
Sub-communities within this community
Collections in this community
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Centre for Clinical Brain Sciences Collection
General collection for Centre for Clinical Brain Sciences (CCBS) -
Derived Data from ADNI (Alzheimer’s Disease Neuroimaging Initiative)
Research using derived data from the ADNI -
Digital Brain Atlases
Brain atlases for assessing different markers of cerebral small vessel disease -
LINCHPIN (Lothian IntraCerebral Haemorrhage, Pathology, Imaging and Neurological Outcome) data
This collection contains data from a clinico-radio-pathological case control study of the causes of intracerebral haemorrhage, based on a community-based inception cohort study in Lothian. -
Potentially serious incidental findings
Data for projects on the epidemiology and impact on participants and health services of potentially serious incidental findings on brain and body magnetic resonance imaging -
REstart or STop Antithrombotics Randomised Trial
RESTART clinical trial -
Search Strategies
Search method protocols and search strategies -
SoSTART - Start or STop Anticoagulants Randomised Trial
SoSTART clinical trial
Recent Submissions
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Measurements of a perivascular spaces magnetic resonance imaging physical phantom and correspondent digital reference object model
Magnetic Resonance Imaging (MRI) visible perivascular spaces (PVS) have been associated with age, decline in cognitive abilities, interrupted sleep, and markers of small vessel disease. Therefore, several computational ... -
Pax6 Developmental Synaptome Atlas
Neurodevelopmental disorders of genetic origin delay the acquisition of normal abilities and cause disabling phenotypes. Nevertheless, spontaneous attenuation and even complete amelioration of symptoms in early childhood ... -
Search strategies for retrieval of references to support a rapid literature review of health inequalities in stroke commissioned by the Stroke Association
Stroke association MEDLINEv2.1 Joshua David Cheyne (JDC), Ramona Naicker (RN), and Verity Longley (VL) editions. This collection of search strategies was designed and constructed to support a rapid literature ... -
HeadOn feasibility study
This is the dataset generated from the HeadOn clinical feasibility study which examined the usability and acceptability of a digital health intervention for concussion. The study took place between November 2021 to April ... -
MATLAB-based framework for simulating and processing BOLD CVR data
Cerebrovascular reactivity (CVR) is of interest in cerebrovascular diseases to assess the health of cerebral blood vessels. This software contains MATLAB scripts designed to simulate BOLD-CVR MRI experiments using hypercapnia ... -
iRobotSurgeon Survey dataset
The iRobotSurgeon survey aimed to explore public opinion towards the issue of liability with robotic surgical systems. The survey included five hypothetical scenarios where a patient comes to harm and the respondent needs ... -
3 T BOLD CVR data from healthy volunteers suitable for within-day repeatability analyses
We aimed to assess the repeatability of CVR measurements using 3 T BOLD MRI and a fixed CO2 inspired gas challenge. Therefore, we recruited healthy volunteers. Each had two CVR scans in two separate within-day MRI sessions. ... -
Views on sharing mental and physical health data among people with and without experience of mental illness
This dataset contains responses from an online survey of 2187 participants primarily located in the UK. All participants stated that they had used the UK National Health Service (NHS) at some time in their lives. The data ... -
SoSTART trial main results dataset: documentation and request form
Analysis dataset for the SoSTART trial main results (https://doi.org/10.1016/S1474-4422(21)00264-7). This dataset contains all the descriptive information about the data. Including protocol, statistical analysis plan, ... -
RESTART Extended Follow Up Dataset
Analysis dataset used for the RESTART extended follow up results paper in 2021 (doi:10.1001/jamaneurol.2021.2956). This dataset contains the data dictionary and statistical analysis plan form the RESTART extended ... -
Pax6 Developmental Synaptome Atlas
Neurodevelopmental disorders of genetic origin delay the acquisition of normal abilities and cause disabling phenotypes. Spontaneous attenuation and even complete amelioration of symptoms in early childhood and adolescence ... -
SUPERSEDED - Views on sharing mental and physical health data among people with and without experience of mental illness
This dataset contains responses from an online survey of 2187 participants primarily located in the UK. All participants stated that they had used the UK National Health Service (NHS) at some time in their lives. The data ... -
Methylome-wide association study of early life stressors and adult mental health
The environment and events that we are exposed to in utero, during birth and in early childhood influence our future physical and mental health. The underlying mechanisms that lead to these outcomes are unclear, but long-term ... -
RESTART trial main results dataset
Analysis dataset used for the RESTART main results and imaging sub-study results papers in 2019 -
Charting the Impact of Bilingualism for Autistic and Non-Autistic Children
The overall aim of this research is to ask how growing up in a bilingual environment affects the linguistic, cognitive and social development of children and, importantly, do these developmental effects differ for children ... -
Search strategy for retrieval of references on thrombolysis for acute ischaemic stroke in MEDLINE Ovid
Constructed using the MEDLINE Ovid platform, this search strategy contains 24 separate search lines and incorporates a combination of Medical Subject Headings (MeSH) from the National Library of Medicine, uncontrolled ... -
PSD95 Lifetime Synaptome Atlas of the mouse brain.
Where memories are stored in the brain and how the capacity to learn and remember changes with age are poorly understood. Synapse proteins are necessary for all behaviour and their lifetime may instruct us on how memories ... -
Metrics for quality control of results from super-resolution machine-learning algorithms – Data extracted from publications in the period 2017- May 2021
The quality enhancement and restoration of poor-quality low-resolution magnetic resonance (MR) data are paramount for improving patient care, accuracy in diagnosis and quality in clinical research. Since 2017, with the ... -
White Matter Hyperintensities Evolution Patterns 1 Year Post-lacunar Stroke and their association with post-stroke cognition
Lacunar strokes are a common type of ischemic stroke. They are associated with long-term disability, but the factors affecting the dynamic of the infarcted lesion and the brain imaging features associated with them, ... -
Systematic Review and Meta-Analysis on incidence and risk of stroke in individuals with long-term exposure to air pollutants
Exposure to air pollution is now recognized globally by governments, leading research scientists, and civil society as one of the greatest public health hazards of the 21st century. Stroke is a major cause of disability ...
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