Centre for Clinical Brain Sciences
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Research at CCBS is multi-disciplinary, spanning a wide spectrum of methodologies from molecular analyses through human stem cell biology to neuroimaging and clinical trials.
Sub-communities within this community
Collections in this community
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Centre for Clinical Brain Sciences Collection
General collection for Centre for Clinical Brain Sciences (CCBS) -
Derived Data from ADNI (Alzheimer’s Disease Neuroimaging Initiative)
Research using derived data from the ADNI -
Digital Brain Atlases
Brain atlases for assessing different markers of cerebral small vessel disease -
LINCHPIN (Lothian IntraCerebral Haemorrhage, Pathology, Imaging and Neurological Outcome) data
This collection contains data from a clinico-radio-pathological case control study of the causes of intracerebral haemorrhage, based on a community-based inception cohort study in Lothian. -
Potentially serious incidental findings
Data for projects on the epidemiology and impact on participants and health services of potentially serious incidental findings on brain and body magnetic resonance imaging -
REstart or STop Antithrombotics Randomised Trial
RESTART clinical trial -
Search Strategies
Search method protocols and search strategies -
SoSTART - Start or STop Anticoagulants Randomised Trial
SoSTART clinical trial
Recent Submissions
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SoSTART trial main results dataset: documentation and request form
Analysis dataset for the SoSTART trial main results (https://doi.org/10.1016/S1474-4422(21)00264-7). This dataset contains all the descriptive information about the data. Including protocol, statistical analysis plan, ... -
RESTART Extended Follow Up Dataset
Analysis dataset used for the RESTART extended follow up results paper in 2021 (doi:10.1001/jamaneurol.2021.2956). This dataset contains the data dictionary and statistical analysis plan form the RESTART extended ... -
Pax6 Developmental Synaptome Atlas
Neurodevelopmental disorders of genetic origin delay the acquisition of normal abilities and cause disabling phenotypes. Spontaneous attenuation and even complete amelioration of symptoms in early childhood and adolescence ... -
Views on sharing mental and physical health data among people with and without experience of mental illness
This dataset contains responses from an online survey of 2187 participants primarily located in the UK. All participants stated that they had used the UK National Health Service (NHS) at some time in their lives. The data ... -
Methylome-wide association study of early life stressors and adult mental health
The environment and events that we are exposed to in utero, during birth and in early childhood influence our future physical and mental health. The underlying mechanisms that lead to these outcomes are unclear, but long-term ... -
RESTART trial main results dataset
Analysis dataset used for the RESTART main results and imaging sub-study results papers in 2019 -
Charting the Impact of Bilingualism for Autistic and Non-Autistic Children
The overall aim of this research is to ask how growing up in a bilingual environment affects the linguistic, cognitive and social development of children and, importantly, do these developmental effects differ for children ... -
Search strategy for retrieval of references on thrombolysis for acute ischaemic stroke in MEDLINE Ovid
Constructed using the MEDLINE Ovid platform, this search strategy contains 24 separate search lines and incorporates a combination of Medical Subject Headings (MeSH) from the National Library of Medicine, uncontrolled ... -
PSD95 Lifetime Synaptome Atlas of the mouse brain.
Where memories are stored in the brain and how the capacity to learn and remember changes with age are poorly understood. Synapse proteins are necessary for all behaviour and their lifetime may instruct us on how memories ... -
Metrics for quality control of results from super-resolution machine-learning algorithms – Data extracted from publications in the period 2017- May 2021
The quality enhancement and restoration of poor-quality low-resolution magnetic resonance (MR) data are paramount for improving patient care, accuracy in diagnosis and quality in clinical research. Since 2017, with the ... -
White Matter Hyperintensities Evolution Patterns 1 Year Post-lacunar Stroke and their association with post-stroke cognition
Lacunar strokes are a common type of ischemic stroke. They are associated with long-term disability, but the factors affecting the dynamic of the infarcted lesion and the brain imaging features associated with them, ... -
Systematic Review and Meta-Analysis on incidence and risk of stroke in individuals with long-term exposure to air pollutants
Exposure to air pollution is now recognized globally by governments, leading research scientists, and civil society as one of the greatest public health hazards of the 21st century. Stroke is a major cause of disability ... -
Systematic review of signal post-processing methods in blood-brain barrier dysfunction assessments via dynamic-contrast enhanced magnetic resonance imaging
DCE-MRI enables quantification of vascular permeability, but current acquisition and processing protocols may be sub-optimal. While the literature has started to recognise this is indeed a problem, decisions concerning the ... -
Systematic Review and Meta-Analysis on the Impact of Polycyclic Aromatic Hydrocarbons Exposure in Cognitive Function and Neurodegeneration in Humans
Exposure to air pollution is now recognized globally by governments, leading research scientists, and civil society as one of the greatest public health hazards of the 21st century. Polycyclic aromatic hydrocarbons (PAH) ... -
Human Brain Atlases across the lifespan – Anatomical Segmentations
Dickie and colleagues generated seven age-specific brain tissue sets/atlases of T1-weighted brain MRI illustrative of the adult lifespan from 25 to 92 years, which are representative of the atrophy and neurovascular health ... -
Magnetisation transfer saturation (MTsat) processing
MATLAB processing script and functions for MTsat and MTR parametric maps with example dataset and processed output. -
Associations between alcohol use and accelerated biological ageing
Data supporting the manuscript "Associations between alcohol use and accelerated biological ageing". Specifically: Genome Wide Association Study of brain age. -
Epilepsy-related mortality during the COVID-19 pandemic: a nationwide study of routine Scottish data
Methods: This was a national, population-based, cross-sectional study of routinely-collected mortality and demographic data pertaining to March–August of 2020 (COVID-19 pandemic) compared to the corresponding periods in ... -
Search strategies for retrieval of references for effective interventions to support the resilience and mental health of frontline health and social care staff during a global health crisis and following de-escalation
These searches were designed constructed between April and May 2020 to support a series of evidence reviews designed to retrieve all potential references for interventions or management strategies to support the resilience ... -
Search strategies designed to retrieve all references on coronavirus (COVID-19) and stroke healthcare
These search strategies were designed and constructed between May and July 2020. They are designed to retrieve all potential references in stroke healthcare and medicine (including transient ischaemic attack, cerebral small ...
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