Molecular, Genetic and Population Health Sciences
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Research undertaken at Molecular, Genetic and Population Health Sciences is largely based in the Institute of Genetics and Molecular Medicine, and within its component research centres (including the MRC Human Genetics Unit and the Edinburgh Cancer Research Centre) and in the Usher Institute for Population Health Sciences & Informatics.
Image: CC-BY Baldock et. al https://doi.org/10.7488/ds/749
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Institute of Genetics and Cancer
Formerly the IGMM - Institute of Genetics and Molecular Medicine -
Usher Institute
Molecular, Genetic and Population Health Sciences
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BayesR+ GWAS - Genome and epigenome wide studies of plasma protein biomarkers for Alzheimer's disease implicate TBCA and TREM2 in disease risk
This dataset represents one of two datasets that correspond to the study: "Genome and epigenome wide studies of plasma protein biomarkers for Alzheimer's disease implicate TBCA and TREM2 in disease risk". The datasets ... -
BayesR+ EWAS - Genome and epigenome wide studies of plasma protein biomarkers for Alzheimer's disease implicate TBCA and TREM2 in disease risk
This dataset represents one of two datasets that correspond to the study: "Genome and epigenome wide studies of plasma protein biomarkers for Alzheimer's disease implicate TBCA and TREM2 in disease risk". The datasets ... -
GWAS summary statistics pertaining to the publication "Same role but different actors: genetic regulation of post-translational modification of two distinct proteins"
Post-translational modifications diversify protein functions and dynamically coordinate their signalling networks, influencing most aspects of cell physiology. Nevertheless, their genetic regulation or influence on complex ... -
An in vitro - agent-based modelling approach to optimisation of culture medium for generating muscle cells
Image data used in the study "An in vitro - agent-based modelling approach to optimisation of culture medium for generating muscle cells" Images of myotube formation stained with a-actinin (Actin) and DAPI (Nuclei). -
SUPERSEDED - GWAS summary statistics pertaining to the publication "Same role but different actors: genetic regulation of post-translational modification of two distinct proteins"
## This item has been replaced by the one which can be found at https://datashare.ed.ac.uk/handle/10283/4088 ## Post-translational modifications (PTMs) diversify protein functions and dynamically coordinate their signalling ... -
Supplementary Tables for David W Clark's PhD Thesis "Inbreeding depression on human complex traits"
Appendix tables from the doctoral thesis of David W Clark "Inbreeding depression on human complex traits". -
Traveller Genes Data Dictionary
Traveller Genes is a research study supported by the Traveller community. We're looking at the genetics, origins and health of over 200 volunteers who have at least two grandparents who are or were Travellers. This includes ... -
Pathogenic loss-of-function, gain-of-function and dominant-negative mutations have profoundly different effects on protein structure: implications for variant effect prediction
The dataset contains all the protein variants, their annotations and variant effect predictor scores used in the analysis outlined in our study. Abstract of the study: Most known pathogenic mutations occur in protein-coding ... -
Community use of digital auscultation to improve diagnosis of paediatric pneumonia in Sylhet, Bangladesh
We are collecting data on general physical health, clinical signs, oxygen saturation and lung sound record from children. We are also collecting household socio-economic data of enrolled children. We are collecting those ... -
Whole slide images of armadillo liver from M.leprae dataset
Whole slide images of H&E stained sections of liver from nine-banded armadillos chronically systemically infected by Mycobacterium leprae, resistant to systemic infection by Mycobacterium leprae, or uninfected. Images ... -
Viking II Data Dictionary
VIKING II was made possible thanks to Medical Research Council (MRC) funding. We aim to better understand what might cause diseases such as heart disease, eye disease, stroke, diabetes and others by inviting 4,000 people ... -
Wnt Pathway Analysis mapped gene-expression data
We provide a unique dataset of 3D mapped gene expression patterns that operate within a vital signalling system for normal development, openly available to the scientific community for further analysis. The associated ... -
Wnt Pathway Analysis mapped gene-expression point-cloud data
We provide a unique dataset of 3D mapped gene expression patterns that operate within a vital signalling system for normal development, openly available to the scientific community for further analysis. The associated ... -
Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2019: a systematic analysis
This dataset provides the aggregated data on RSV morbidity and mortality in children younger than 5 years globally. The data were collected from a systematic literature review and from a global collaboration network named ... -
Interface size drives cotranslational assembly of protein complexes
The dataset contains an R notebook and the associated data files that are parsed by the analysis script. The R notebook is an R Markdown document written in R version 4.1.1, and it is best viewed, edited, and run in R ... -
Supporting data for: "The properties of human disease mutations at protein interfaces"
ABSTRACT: The assembly of proteins into complexes and interactions with other biomolecules are often vital for their biological function. While it is known that mutations at protein interfaces have a high potential to ... -
Extended Supplementary Tables for Thesis: "Omics Measures of Ageing and Disease Susceptibility" by Erin Macdonald-Dunlop
Extended supplementary tables from the thesis entitled "Omics Measures of Ageing and Disease Susceptibility" by Erin Macdonald-Dunlop. Supplementary tables for the three results chapters are in the corresponding ... -
Qualitative study to inform intervention development for behaviour change in adults with chronic lung disease in rural India
This qualitative research informed the Theory of Planned Behaviour (TPB)-based intervention development. This dataset was generated as part of formative research conducted on patients of chronic respiratory disease (CRD), ... -
Mutational bias in spermatogonia impacts the anatomy of regulatory sites in the human genome
ATAC-Seq reports local chromatin accessibility and provides a snapshot of active regulatory regions and genomic regions occupied by DNA-binding proteins in a given tissue. We used ATAC-Seq to identify open chromatin sites ... -
Global hospital admissions and in-hospital mortality associated with all-cause and virus-specific acute lower respiratory infections in children and adolescents aged 5-19 years between 1995 and 2019
This dataset includes the data for the paper entitled "Global hospital admissions and in-hospital mortality associated with all-cause and virus-specific acute lower respiratory infections in children and adolescents ...
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