Molecular, Genetic and Population Health Sciences
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Research undertaken at Molecular, Genetic and Population Health Sciences is largely based in the Institute of Genetics and Molecular Medicine, and within its component research centres (including the MRC Human Genetics Unit and the Edinburgh Cancer Research Centre) and in the Usher Institute for Population Health Sciences & Informatics.
Image: CC-BY Baldock et. al https://doi.org/10.7488/ds/749
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Usher Institute
Molecular, Genetic and Population Health Sciences
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Polygenic risk scores and GWAS summary statistics for an analysis of the contribution of common risk variants to multiple sclerosis in Orkney and Shetland
Orkney and Shetland, the population isolates which make up the Northern Isles of Scotland, are of particular interest to multiple sclerosis (MS) research. While MS prevalence is high in Scotland, Orkney has the highest ... -
GWAMA summary data for morning plasma cortisol from the Cortisol Network (CORNET) Consortium 2021 (n=25,314)
The stress hormone cortisol modulates fuel metabolism, cardiovascular homoeostasis, mood, inflammation and cognition. The CORtisol NETwork (CORNET) consortium previously identified a single locus associated with morning ... -
Supplementary File 1: Key findings from downloaded COVID-19 information for those categorised as high-risk (20 April 2020)
Data supporting McClatchey et al "COVID-19 information for people living with asthma: A rapid review of publicly available information" JACI: In practice https://doi.org/10.1016/j.jaip.2021.01.003 . Abstract: In 2020, ... -
Large scale phenotype imputation and in vivo functional validation implicate ADAMTS14 as a novel adiposity gene - Supplementary data
Obesity remains an unmet global health burden. Detrimental anatomical distribution of body fat is a major driver of obesity-mediated mortality risk and is demonstrably heritable. However, our understanding of the full ... -
Genetically independent phenotype analysis identifies LPA and VCAM1 as drug targets for human ageing
Data supporting the manuscript Timmers et. al (2021) bioRXiv https://doi.org/10.1101/2021.01.22.427837 . -
Ergonomic assessment of the Dix-Hallpike’s test
Abstract Objectives: Numerous tasks carried out in the otolaryngology clinic increase the chances of developing injury among practitioners. To mitigate this, we aim to observe the risk of musculoskeletal injury in ... -
SUPERSEDED - Supplementary File 1: Key findings from downloaded COVID-19 information for those categorised as high-risk (20 April 2020)
## SUPERSEDED - this item has been replaced by the one which can be found at https://doi.org/10.7488/ds/2982 . ## Data supporting McClatchey et al "COVID-19 information for people living with asthma: A rapid review of ... -
Medication-Wide Association Study of Dementia
Dataset and code list from medication-wide association study of dementia, using the Secure Anonymised Information Linkage databank Dementia electronic Cohort (SAIL-DeC). The dataset contains the hazard ratios and p-values ... -
Summary statistics from epigenome-wide association studies and meta-analysis comparing APOE ε4 and APOE ε2 allele carriers in Generation Scotland
These datasets contain full summary statistics for epigenome-wide association studies (EWASs) carried out using two methylation samples from the Generation Scotland: Scottish Family Health Study to investigate associations ... -
Cornea resistance factor GWAS in the UK Biobank
Summary statistics from the genome-wide association study (GWAS) of cornea resistance factor (CRF) of 76,029 UK Biobank samples of British ancestry obtained through the application number 19655. The CRF analysis was ... -
Risk factors for RSV associated acute lower respiratory infection poor outcome and mortality in young children
Respiratory syncytial virus associated acute lower respiratory infection (RSV-ALRI) constitutes a substantial disease burden in young children. We aimed to identify all studies investigating the risk factors of RSV-ALRI ... -
Disease burden estimates of RSV associated with acute respiratory infections in adults with comorbidity
Respiratory syncytial virus associated acute respiratory infection (RSV-ARI) constitutes a substantial disease burden in adults, especially in those with comorbidities. We aimed to identify all studies worldwide investigating ... -
"The genetic underpinnings of adiposity: from GWAS discovery to functional characterisation" extended supplementary data
Two extended supplementary tables, needed for the submission of a thesis in fulfilment of a PhD in Precision Medicine at the University of Edinburgh in 2020. This upload includes 2 files. The first file ("TableS1_iDXA_ ... -
Dissertation 2020 R Code
R code in support of University of Edinburgh Masters thesis "Racial Differences in the Predictive Ability of Apgar Scores: A Quantitative Analysis". The source data for the anlaysis was the National Vital Statistics Cohort ... -
Pervasive lesion segregation shapes cancer genome evolution
Cancers arise through the acquisition of oncogenic mutations and grow by clonal expansion. Here we reveal that most mutagenic DNA lesions are not resolved into a mutated DNA base pair within a single cell cycle. Instead, ... -
Global burden of acute lower respiratory infection associated with human parainfluenza virus in children under five years for 2018: a systematic review and meta-analysis
We provide the datasets used in this study. The datasets include: (1) incidence rates of hPIV associated ALRI (see "ALRI" file); (2) hospitalisation rates of hPIV associated ALRI (see "Hos" file); (3) hospitalisation rates ... -
Global burden of acute lower respiratory infection associated with human metapneumovirus in children under five years for 2018: a systematic review and modelling study
We provide datasets used in this study in this folder. The datasets include (1) the incidence rate of hMPV associated ALRI (see "ALRI" file); (2) hospitalisation rates of hMPV associated ALRI (see "Hos" file); (3) ... -
Birth weight associations with DNA methylation differences in an adult population
The Developmental Origins Health and Disease (DOHaD) theory predicts that prenatal and early life events shape adult health outcomes. Birth weight is a useful indicator of the foetal experience, and has been associated ... -
GenomeArtiFinder variant include list
Background: The loss of genetic diversity in segments over a genome (loss-of-heterozygosity, LOH) is a common occurrence in many types of cancer. By analysing patterns of preferential allelic retention during LOH in ...
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