Chloromethyl-triazole: A new motif for site-selective pseudo-acylation of proteins
Date Available
2016-09-16Type
datasetData Creator
Brewster, Richard CGavins, Georgina C
Günthardt, Barbara
Farr, Sarah
Webb, Kimberly M
Voigt, Philipp
Hulme, Alison
Publisher
University of Edinburgh. School of ChemistryRelation (Is Referenced By)
https://doi.org/10.1039/c6cc06801dMetadata
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Citation
Brewster, Richard C; Gavins, Georgina C; Günthardt, Barbara; Farr, Sarah; Webb, Kimberly M; Voigt, Philipp; Hulme, Alison. (2016). Chloromethyl-triazole: A new motif for site-selective pseudo-acylation of proteins, [dataset]. University of Edinburgh. School of Chemistry. https://doi.org/10.7488/ds/1484.Description
Rapid, site-selective modification of cysteine residues with chloromethyl-triazole derivatives generates pseudo-acyl sLys motifs, mimicking important post-translational modifications. Near-native biotinylation of peptide and protein substrates is shown to be site-selective and modified histone H4 retains functional activity.
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