Institute of Genetics and Molecular Medicine
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The Institute of Genetics and Molecular Medicine (IGMM) is comprised of the MRC Human Genetics Unit, the University of Edinburgh Centre for Genomic and Experimental Medicine and the Edinburgh Cancer Research Centre.
Sub-communities within this community
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Medical Research Council Human Genetics Unit
Advancing the understanding of genetic factors implicated in human disease and normal and abnormal development and physiology
Recent Submissions
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GWAMA summary data for morning plasma cortisol from the Cortisol Network (CORNET) Consortium 2021 (n=25,314)
The stress hormone cortisol modulates fuel metabolism, cardiovascular homoeostasis, mood, inflammation and cognition. The CORtisol NETwork (CORNET) consortium previously identified a single locus associated with morning ... -
Genetically independent phenotype analysis identifies LPA and VCAM1 as drug targets for human ageing
Data supporting the manuscript Timmers et. al (2021) bioRXiv https://doi.org/10.1101/2021.01.22.427837 . -
Summary statistics from epigenome-wide association studies and meta-analysis comparing APOE ε4 and APOE ε2 allele carriers in Generation Scotland
These datasets contain full summary statistics for epigenome-wide association studies (EWASs) carried out using two methylation samples from the Generation Scotland: Scottish Family Health Study to investigate associations ... -
Cornea resistance factor GWAS in the UK Biobank
Summary statistics from the genome-wide association study (GWAS) of cornea resistance factor (CRF) of 76,029 UK Biobank samples of British ancestry obtained through the application number 19655. The CRF analysis was ... -
Pervasive lesion segregation shapes cancer genome evolution
Cancers arise through the acquisition of oncogenic mutations and grow by clonal expansion. Here we reveal that most mutagenic DNA lesions are not resolved into a mutated DNA base pair within a single cell cycle. Instead, ... -
Birth weight associations with DNA methylation differences in an adult population
The Developmental Origins Health and Disease (DOHaD) theory predicts that prenatal and early life events shape adult health outcomes. Birth weight is a useful indicator of the foetal experience, and has been associated ... -
GenomeArtiFinder variant include list
Background: The loss of genetic diversity in segments over a genome (loss-of-heterozygosity, LOH) is a common occurrence in many types of cancer. By analysing patterns of preferential allelic retention during LOH in ... -
Dataset pertaining to the publication "Quantitative levels of serum N-glycans in type 1 diabetes and their association with kidney disease"
The files are comma separated and contain measurements for 46 N-glycan peaks on 1581 serum samples (corresponding to 1565 unique participants) from SDRNT1BIO and from a pool of healthy controls. N-glycan peaks are expressed ... -
Protein genome-wide associations from the paper 'Linking protein to phenotype with Mendelian Randomization detects 38 proteins with causal roles in human diseases and traits'.
Data in support of the manuscript "Linking protein to phenotype with Mendelian Randomization detects 38 proteins with causal roles in human diseases and traits". -
VEP predictions for ClinVar and gnomAD variants
Variant effect predictions and DMS data for ClinVar and gnomAD variants in BRCA1, P53, CALM1, PTEN, HRAS and TPK1. -
Variant effect predictions for human, yeast, bacterial and viral proteins
Variant effect predictions made by DEOGEN2, Envision, FATHMM, Fathmm-MKL, FathmmXF, MPC, MutationTaster, MutPred, NetDiseaseSNP, PhD_SNP, PolyPhen2 (HumDiv and HumVar), PonPS, PonP2, PrimateAI, S3D-PROF, SNAP2, SNPs&GO, ... -
Genome-wide association summary statistics of antidepressant treatment resistance meta-analysis
Data from Wigmore et al "Genome-wide association study of antidepressant treatment resistance in a population-based cohort using health service prescription data and meta-analysis with GENDEP". The Pharmacogenomics Journal ... -
A Celebration of Scottish Health Cohort Studies: Participants' attitudes towards data research
BACKGROUND. The UK hosts many of the world’s longest running prospective longitudinal birth cohort studies. These projects make repeated observations of their participants and use this data to explore health outcomes ... -
Insights into the genetic basis of retinal detachment
Dataset of genome-wide association meta-analysis summary statistics associated with the publication “Insights into the genetic basis of retinal detachment” available at HMG: DOI: 10.1093/hmg/ddz294. If you use this dataset, ... -
Generation Scotland Age x Sex Epigenome Wide Association Study Summary Statistics
This directory contains full summary statistics for the following EWAS studies in the Generation Scotland cohort. Epigenome-wide autosomal sites associated with chronological age with concordant effect sizes in the ... -
Dataset 2 pertaining to the publication "Exploration of haplotype research consortium imputation for genome-wide association studies in 20,032 Generation Scotland participants"
The Generation Scotland: Scottish Family Health Study (GS:SFHS) is a family-based population cohort with DNA, biological samples, socio-demographic, psychological and clinical data from ~24,000 adult volunteers across ... -
Generation Scotland Survey Monkey data
Generation Scotland (GS) conducted a recontact survey on ~7,000 participants who could be contacted by email. The survey used Survey Monkey Inc. to understand GS participant opinions on health research. A total of 2,316 ... -
Supplementary data to "Ligand binding site structure shapes folding, assembly and degradation of homomeric protein complexes" by G. Abrusan and J.A. Marsh
The structure of ligand binding sites has profound consequences for the evolution of function of protein complexes, particularly in homomers. Homomers with multichain binding sites (MBS) are characterized with more conserved ... -
Comparison of DNA methylation profiles from Generation Scotland blood samples stored on Whatman FTA cards and in EDTA tubes: EWAS summary statistics
This dataset contains summary statistics for the epigenome-wide association studies (EWASs) performed to ascertain the feasibility of profiling DNA methylation using dried blood spot (DBS) DNA from Generation Scotland ... -
Supplementary data to "Ligand binding site structure shapes allosteric signal transduction and the evolution of allostery in protein complexes" by G. Abrusan and J.A. Marsh
The structure of ligand binding sites has been shown to profoundly influence the evolution of function in homomeric protein complexes. Complexes with multi-chain binding sites (MBSs) have more conserved quaternary structure, ...
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