Items in this Collection

  • Pax6 Developmental Synaptome Atlas 

    Tomas-Roca, Laura; Qiu, Zhen; Fransén, Erik; Grant, Seth
    Neurodevelopmental disorders of genetic origin delay the acquisition of normal abilities and cause disabling phenotypes. Nevertheless, spontaneous attenuation and even complete amelioration of symptoms in early childhood ...
  • Pax6 Developmental Synaptome Atlas 

    Laura, Tomas-Roca; Qiu, Zhen; Fransén, Erik; Grant, Seth
    Neurodevelopmental disorders of genetic origin delay the acquisition of normal abilities and cause disabling phenotypes. Spontaneous attenuation and even complete amelioration of symptoms in early childhood and adolescence ...
  • PSD95 Lifetime Synaptome Atlas of the mouse brain. 

    Bulovaite, Edita; Qiu, Zhen; Grant, Seth
    Where memories are stored in the brain and how the capacity to learn and remember changes with age are poorly understood. Synapse proteins are necessary for all behaviour and their lifetime may instruct us on how memories ...
  • Mouse Lifespan Synaptome Atlas dataset 

    Cizeron, M; Qiu, Z; Koniaris, B; Gokhale, R; Komiyama, N; Fransén, E; Grant, SGN
    How synapses change molecularly during the lifespan and across all brain circuits is unknown. We analyzed the protein composition of billions of individual synapses from birth to old age on a brain-wide scale in the mouse, ...
  • Proteomic analysis of postsynaptic proteins in regions of the human neocortex 

    Grant, Seth; Roy, Marcia; Sorokina, Oksana; Skene, Nathan; Simonnet, Clemence; Smith, Colin; Armstrong, J Douglas
    The postsynaptic proteome of excitatory synapses comprises ~1,000 highly conserved proteins that control the behavioral repertoire and mutations disrupting their function cause >130 brain diseases. Here, we document the ...
  • SUPERSEDED - Synaptome data with individual synapse parameters, types and subtypes for 10 representative sagittal mouse brain sections across the lifespan 

    Qiu, Zhen; Koniaris, Babis; Grant, Seth
    ## This item has been replaced by the one which can be found at https://doi.org/10.7488/ds/2796 ## How synapses change molecularly during the lifespan and across all brain circuits is unknown. We analyzed the protein ...
  • A synapse proteome resource for mouse brain regions 

    Roy, Marcia; Sorokina, Oksana; McLean, Colin; Tapia Gonzalez, Silvia; DeFelipe, Javier; Armstrong, J Douglas; Grant, Seth
    Data supporting the paper Roy, M.; Sorokina, O.; McLean, C.; Tapia-González, S.; DeFelipe, J.; Armstrong, J.D.; Grant, S.G.N. Regional Diversity in the Postsynaptic Proteome of the Mouse Brain. Proteomes 2018, 6, 31. ...
  • SUPERSEDED - A synapse proteome resource for mouse brain regions 

    Roy, Marcia; Sorokina, Oksana; McLean, Colin; Gonzalez, Silvia Tapia; DeFelipe, Javier; Armstrong, J Douglas; Grant, Seth
    ## This item has been replaced by the one which can be found at https://doi.org/10.7488/ds/2399 . ## Data supporting the accepted manuscript Roy et al "Postsynaptic proteome regional signatures define architecture, function ...
  • Synaptome data with individual synapse parameters, types and subtypes across the 5 coronal mouse brain sections 

    Qiu, Zhen; Koniaris, Babis; Grant, Seth
    Synapses are found in vast numbers in the brain and contain complex proteomes. We developed genetic labeling and imaging methods to examine synaptic proteins in individual excitatory synapses across all regions of the mouse ...
  • SUPERSEDED - Proteomic analysis of postsynaptic proteins in regions of the human neocortex 

    Grant, Seth; Roy, Marcia; Sorokina, Oksana; Skene, Nathan; Simonnet, Clemence; Smith, Colin; Armstrong, J Douglas
    ## This item has been replaced by the one which can be found at: https://doi.org/10.7488/ds/2789 ##
  • SUPERSEDED - A synapse proteome resource for mouse brain regions 

    Roy, Marcia; Sorokina, Oksana; McLean, Colin; Gonzalez, Silvia Tapia; DeFelipe, Javier; Armstrong, J Douglas; Grant, Seth
    ## This item has been replaced by the one which can be found at https://doi.org/10.7488/ds/2399 . ##
  • ## SUPERSEDED - Postsynaptic proteome data from the human neocortex ## 

    Roy, Marcia; Sorokina, Oksana; Skene, Nathan; Simonnet, Clemence; Smith, Colin; Armstrong, J Douglas; Grant, Seth
    ## This dataset has been replaced by the one which can be found at https://doi.org/10.7488/ds/2789 ## Brain tissue proteome data from four human subjects, resident in the UK.
  • SUPERSEDED - Synaptic Proteome Across the 7 Integral Regions of the Mouse Brain 

    Roy, Marcia; Grant, Seth; Le Bihan, Thierry; Sorokina, Oksana
    # This item has been replaced by the one at https://doi.org/10.7488/ds/2399 . # The integral regions of the mouse brain are unique in their structure, cellular composition and biochemical function. Together, they control ...