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Structural basis for DNA 3'-end processing by human Tyrosyl-DNA phosphodiesterase 1

Flett, Fiona J; Interthal, Heidrun; Mackay, Logan

Tyrosyl-DNA phosphodiesterase (Tdp1) is a DNA 3'-end processing enzyme that repairs topoisomerase 1B-induced DNA damage. We use a new tool combining site-specific DNA-protein cross-linking with mass spectrometry to identify ...