The Roslin Institute at the University of Edinburgh is a BBSRC-funded institute. The Institute undertakes research within the framework of BBSRC Institute Strategic Programmes focussed on the health and welfare of animals, and applications of basic animal sciences in human and veterinary medicine, the livestock industry and food security.

The Roslin Institute's mission is to gain fundamental understanding of genetic, cellular, organ and systems bioscience underpinning common mechanisms of animal development and pathology, and to drive this into prevention and treatment of important veterinary diseases and develop sustainable farm animal production systems.

The Roslin Institute aims to enhance the lives of animals and humans through world class research in animal biology.

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Recent Submissions

  • Boran BovineHD SNP data 

    Prendergast, James
    BovineHD SNP (single nucleotide polymorphism) data for 82 Boran cattle.
  • The impact of acute loud noise on the behaviour of laboratory birds - data 

    Corbani, Tayanne; Healy, Susan; Martin, Jessica
    We examined whether exposure to a routine laboratory noise, a low-frequency fire alarm test, induced behavioural changes in laboratory zebra finches (Taeniopygia guttata). Twenty-four breeding pairs of zebra finches were ...
  • GenOMICC Covid-19 summary statistics European ancestry 

    Pairo-Castineira, Erola; BBSRC - Biotechnology and Biological Sciences Research Council; MRC - Medical Research Council; NIHR - National Institute for Health Research; Bill & Melinda Gates Foundation; University of Edinburgh; Wellcome Trust; Sepsis Research (the Fiona Elizabeth Agnew Trust); Intensive Care Society; UK Department of Health and Social Care; UKRI and LifeArc; EU Platform foR European Preparedness Against (Re-) emerging Epidemics (PREPARE)
    GWAS summary statistics for European ancestry, from the GenOMICC Covid-19 critical illness study. GWAS was performed with 1676 Europeans and 5*1676 controls and validated using 100K Genomics England controls and Generation ...
  • GenOMICC Covid-19 critical illness summary statistics non-European ancestries 

    Pairo-Castineira, Erola; BBSRC - Biotechnology and Biological Sciences Research Council; MRC - Medical Research Council; NIHR - National Institute for Health Research; University of Edinburgh; Wellcome Trust; Sepsis Research (the Fiona Elizabeth Agnew Trust); Intensive Care Society; UK Department of Health and Social Care; UKRI and LifeArc; Bill and Melinda Gates Foundation; EU Platform foR European Preparedness Against (Re-) emerging Epidemics (PREPARE)
    Non-European ancestries GWAS summary statistics for Covid-19 critical illness from the GenOMICC study
  • lentiviral mediated apoE4 transduction in primary neuronal culture 

    Wishart, Thomas
    To identify the molecular changes in signalling pathways triggered by altered apoE4 expression, we used lentiviral transduction to overexpress human apoE4 in 18-21 DIV primary hippocampal neurons. The molecular consequences ...
  • 2020_Thesis_SupplementaryData_s1569052_Tissue-resident immune cells in health and disease: their heterogeneity and associated gene signatures 

    Patir, Anirudh; Freeman, Tom; McColl, Barry
    The dataset includes supplementary figures and tables in support of the University of Edinburgh thesis titled "Tissue-resident immune cells in health and disease: their heterogeneity and associated gene signatures".
  • Staphylococcus aureus secreted lipases do not inhibit innate immune killing mechanisms: Extended Figure 1 

    Sargison, Fiona; Alves, Joana; Pickering, Amy C; Fitzgerald, J Ross
    Staphylococcus aureus pathogenesis is mediated by a plethora of secreted proteins, many of which remain incompletely characterised. For example, S. aureus abundantly secretes two isoforms of the enzyme lipase into the ...
  • XP-EHH and XP-CLR scores across water buffalo and cattle breeds 

    Prendergast, James; Dutta, Prasun; Talenti, Andrea
    This dataset consists of XP-EHH and XP-CLR scores calculated using the hapbin (https://github.com/evotools/hapbin) and xpclr (https://github.com/hardingnj/xpclr) software with default parameters across 79 water buffalo and ...
  • Gene expression in the cardiovascular system of the domestic sheep (Ovis aries) 

    Tsang, Hiu-Gwen; Clark, Emily L; Markby, Greg A; Bush, Stephen J; Hume, David A; Corcoran, Brendan M; MacRae, Vicky E; Summers, Kim M
    This dataset includes gene expression estimates, from RNA-Seq, for seven cardiovascular and one skeletal muscle tissue from the sheep gene expression atlas dataset (https://journals.plos.org/plosgenetics/article?id=10.13 ...
  • Characterisation of a second gain of function EDAR variant, encoding EDAR380R, in East Asia 

    Schoenebeck, Jeffrey; Riddell, Jon; Headon, Denis
    Bash scripts, R scripts, rehh output data.
  • A comparison of livestock movement network-methods and implications for disease control in developing countries 

    Muwonge, Adrian; Bessell, Paul; Porphyre, Thibaud; Motta, Paolo; Rydevik, Gustaf; Devailly, Guillaume; Egbe, Franklyn; Kelly, Robert; Handel, Ian; Mazeri, Stella; Bronsvoort, Mark
    The use of network analysis to support livestock disease control in low middle-income countries (LMICs) has historically been hampered by the cost of generating empirical data in the absence of animal movement recording ...
  • The Infectious Diseases of East African Livestock (IDEAL) Project Database - Stable Snapshot 

    Callaby, Rebecca; Pendarovski, Cezar; Jennings, Amy; Thumbi, Samuel; Van Wyk, Ilana; Mbole-Kariuki, Mary; Kiara, Henry; Toye, Philip; Kemp, Steve; Hanotte, Olivier; Coetzer, Jacobus; Handel, Ian; Woolhouse, Mark; Bronsvoort, Barend
    The Infectious Diseases of East African Livestock (IDEAL) project was a longitudinal cohort study of calf health which was conducted in Western Kenya between 2007-2009. It collected information on 548 East African shorthorn ...
  • CKCS CEL data 

    Markby, Greg
    The dataset is microrarray data collected from canine RNA samples. The experimental design of this project is to perform comparative analysis (unpaired one-way ANOVA) between normal canine mitral valves, late stage Myxomatous ...
  • Comparative profiling of murine CLN1 Thalamus and Cortex at early and late disease timepoints 

    Wishart, Thomas
    CLN1 disease or Infantile neuronal ceroid lipofuscinosis is a fatal inherited neurodegenerative lysosomal storage disease of early childhood with no currently available therapy. CLN1 disease is caused by mutations in the ...
  • Construction of OOEP_IVT, OOEP_CAG, OOEP_VASA and ROSA26_gRNAs plasmids 

    McFarlane, Gus
    These pdf files outline the construction of the four CRISPR/Cas9 gene drive DNA plasmid constructs developed during Gus McFarlane's PhD (2016 to 2020). These files provide important supplementary information to his PhD ...
  • Data for "Pathogen transmission from vaccinated hosts can cause dose-dependent reduction in virulence" 

    Dunn, John R; Cheng, Hans H; Doeschl-Wilson, Andrea; Bailey, Richard I; Chase-Topping, Margo; Mays, Jody; Anacleto, Osvaldo
    # Abstract # Many livestock and increasingly human vaccines are leaky, blocking symptoms without preventing infection or onward transmission. Leakiness is concerning as it increases vaccination coverage required to ...
  • SUPERSEDED - Water buffalo and cattle XPEHH scores across breeds 

    Prendergast, James; Dutta, Prasun; Talenti, Andrea
    ## SUPERSEDED - This dataset has been replaced by the one which can be found at https://doi.org/10.7488/ds/2849 . ## This dataset consists of XP-EHH scores calculated using the hapbin software (https://github.com/evotools/hapbin) ...
  • A putative genomic map for resistance of Bos indicus cattle in Cameroon to bovine tuberculosis 

    Callaby, Rebecca; Kelly, Robert; Mazeri, Stella; Egbe, Franklyn; Benedictus, Lindert; Clark, Emily; Doeschl-Wilson, Andrea; Bronsvoort, Barend; Salavati, Mazdak; Muwonge, Adrian
    Bovine Tuberculosis (bTB) caused by Mycobacterium bovis is a livestock disease of global economic and public health importance. There are currently no effective vaccines available for livestock and so control relies on ...
  • Single cell transcriptional profiling of rat embryonic stem cells defined by Rex1-EGFP reporter expression 

    Burdon, Tom; Meek, Stephen; Joshi, Anagha; Chandra, Tamir
    Rat embryonic stem cells exhibit basal levels of spontaneous differentiation in 2i+LIF (2iL) culture. Expression of a stem cell specific Rex1-EGFP knock-in reporter transgene in rat ESCs was used to isolate functionally ...
  • Metagenome assembled rumen-uncultured genomes (RUGs) 

    Glendinning, Laura
    DNA was sequenced from rumen contents from cattle, sheep, red deer and reindeer. We constructed 391 metagenome assembled rumen-uncultured genomes (RUGs).

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