The Roslin Institute
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The Roslin Institute at the University of Edinburgh is a BBSRC-funded institute. The Institute undertakes research within the framework of BBSRC Institute Strategic Programmes focussed on the health and welfare of animals, and applications of basic animal sciences in human and veterinary medicine, the livestock industry and food security.
The Roslin Institute's mission is to gain fundamental understanding of genetic, cellular, organ and systems bioscience underpinning common mechanisms of animal development and pathology, and to drive this into prevention and treatment of important veterinary diseases and develop sustainable farm animal production systems.
The Roslin Institute aims to enhance the lives of animals and humans through world class research in animal biology.
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CTLGH - Centre for Tropical Livestock Genetics and Health
Tackling global challenges through genetic improvements in tropical livestock -
Functional Genetics and Development
Formerly 'Developmental Biology'
Recent Submissions
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Supplementary files supporting the paper "Microarray profiling emphasizes transcriptomic differences between hippocampal in vivo tissue and in vitro cultures"
Differential expression was performed using the R package "limma" (R package version 3.44.3) (Supplementary files 1-4; 1_diff_expr_WT_cell_vs_tissue, 2_diff_expr_101LL_cell_vs_tissue, 3_diff_expr_cell_WT_ vs_101LL, ... -
Microarray data CEL files supporting the paper "Microarray profiling emphasizes transcriptomic differences between hippocampal in vivo tissue and in vitro cultures"
Affymetrix microarray processing produced 16 (4 WT cell, 4 101LL cell, 4 WT tissue, 4 101LL tissue) probe cell intensity data (CEL) files. Primary hippocampal cell cultures are routinely used as an experimentally accessible ... -
Antigenic diversity in Theileria parva populations from cattle and African buffalo analysed using long read sequencing
East Coast fever (ECF) in cattle is caused by the tick-borne protozoan Theileria parva, and is transmitted by the three-host tick Rhipicephalus appendiculatus. The African buffalo (Syncerus caffer) is the natural host for ... -
Whole genome sequencing SNP data of honey bee drones
Genotype data from processing of whole genome sequence data for 689 honey bee drones representing samples from 14 countries and 7 subspecies. -
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The impact of acute loud noise on the behaviour of laboratory birds - data
We examined whether exposure to a routine laboratory noise, a low-frequency fire alarm test, induced behavioural changes in laboratory zebra finches (Taeniopygia guttata). Twenty-four breeding pairs of zebra finches were ... -
GenOMICC Covid-19 summary statistics European ancestry
GWAS summary statistics for European ancestry, from the GenOMICC Covid-19 critical illness study. GWAS was performed with 1676 Europeans and 5*1676 controls and validated using 100K Genomics England controls and Generation ... -
GenOMICC Covid-19 critical illness summary statistics non-European ancestries
Non-European ancestries GWAS summary statistics for Covid-19 critical illness from the GenOMICC study -
lentiviral mediated apoE4 transduction in primary neuronal culture
To identify the molecular changes in signalling pathways triggered by altered apoE4 expression, we used lentiviral transduction to overexpress human apoE4 in 18-21 DIV primary hippocampal neurons. The molecular consequences ... -
2020_Thesis_SupplementaryData_s1569052_Tissue-resident immune cells in health and disease: their heterogeneity and associated gene signatures
The dataset includes supplementary figures and tables in support of the University of Edinburgh thesis titled "Tissue-resident immune cells in health and disease: their heterogeneity and associated gene signatures". -
Staphylococcus aureus secreted lipases do not inhibit innate immune killing mechanisms: Extended Figure 1
Staphylococcus aureus pathogenesis is mediated by a plethora of secreted proteins, many of which remain incompletely characterised. For example, S. aureus abundantly secretes two isoforms of the enzyme lipase into the ... -
XP-EHH and XP-CLR scores across water buffalo and cattle breeds
This dataset consists of XP-EHH and XP-CLR scores calculated using the hapbin (https://github.com/evotools/hapbin) and xpclr (https://github.com/hardingnj/xpclr) software with default parameters across 79 water buffalo and ... -
Gene expression in the cardiovascular system of the domestic sheep (Ovis aries)
This dataset includes gene expression estimates, from RNA-Seq, for seven cardiovascular and one skeletal muscle tissue from the sheep gene expression atlas dataset (https://journals.plos.org/plosgenetics/article?id=10.13 ... -
Characterisation of a second gain of function EDAR variant, encoding EDAR380R, in East Asia
Bash scripts, R scripts, rehh output data. -
A comparison of livestock movement network-methods and implications for disease control in developing countries
The use of network analysis to support livestock disease control in low middle-income countries (LMICs) has historically been hampered by the cost of generating empirical data in the absence of animal movement recording ... -
The Infectious Diseases of East African Livestock (IDEAL) Project Database - Stable Snapshot
The Infectious Diseases of East African Livestock (IDEAL) project was a longitudinal cohort study of calf health which was conducted in Western Kenya between 2007-2009. It collected information on 548 East African shorthorn ... -
CKCS CEL data
The dataset is microrarray data collected from canine RNA samples. The experimental design of this project is to perform comparative analysis (unpaired one-way ANOVA) between normal canine mitral valves, late stage Myxomatous ... -
Comparative profiling of murine CLN1 Thalamus and Cortex at early and late disease timepoints
CLN1 disease or Infantile neuronal ceroid lipofuscinosis is a fatal inherited neurodegenerative lysosomal storage disease of early childhood with no currently available therapy. CLN1 disease is caused by mutations in the ... -
Construction of OOEP_IVT, OOEP_CAG, OOEP_VASA and ROSA26_gRNAs plasmids
These pdf files outline the construction of the four CRISPR/Cas9 gene drive DNA plasmid constructs developed during Gus McFarlane's PhD (2016 to 2020). These files provide important supplementary information to his PhD ... -
Data for "Pathogen transmission from vaccinated hosts can cause dose-dependent reduction in virulence"
# Abstract # Many livestock and increasingly human vaccines are leaky, blocking symptoms without preventing infection or onward transmission. Leakiness is concerning as it increases vaccination coverage required to ...
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