Browsing The Roslin Institute by Date Accessioned
Now showing items 1-20 of 68
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Identification of miRNAs associated with the follicular-luteal transition in the ruminant ovary
(University of Edinburgh. Roslin Institute, 2013-03-26)Little is known about the involvement of microRNAs (miRNAs) in the follicular-luteal transition. The aim of this study was to identify genome-wide changes in miRNAs associated with follicular differentiation in sheep. miRNA ... -
RNA composition metrics
Mutating RNA virus genomes to alter codon pair (CP) frequencies and reduce translation efficiency has been advocated as a method to generate safe, attenuated virus vaccines. However, selection for disfavoured CPs leads to ... -
hapbin: An efficient program for performing haplotype based scans for positive selection in large genomic datasets
These files contain genome-wide integrated haplotype scores (iHS) for each of the 26 populations in the phase 3 release of the 1000 genomes project. iHS were calculated using the hapbin program that can be downloaded from ... -
Somatic Cell Nuclear Transfer (Cloning) Efficiency
Cloning by nuclear transfer from adult somatic cells is a remarkable demonstration of developmental plasticity. When a nucleus is placed in oocyte cytoplasm, the changes in chromatin structure that govern differentiation ... -
Spreadsheet for Sample Size Calculation
Spreadsheet to estimate sample size. Alternatively power or the difference to detect (delta) may be obtained for a given sample size. Covers situations with different variability for groups and different group sizes. ... -
Datasets of genes expressed in the mouse nervous system
Data supporting paper Summers K et al (In Submission). -
Canine medial coronoid process disease microarray data
The objective of this study was to identify differentially expressed genes associated with the process of medial coronoid process disease, primary to the development of osteoarthritis. The data were produced using Affymetrix ... -
Cytokine stimulation of canine chondrocytes and osteoblasts
In vitro modelling of osteoarthritis typically uses cytokines to induce a catabolic phenotype in joint cells. This model was used to identify the response to a cytokine parameter identified as most representative of early ... -
Stimulation of canine joint cells to model osteoarthritis
Canine chondrocytes and osteoblasts were embedded in an agarose matrix and simultaneously stimulated with cytokines whilst being cyclically compressed. Both cell types were compressed for 4 hours at 1 Hz followed by a 24 ... -
Cyclic compression of canine joint cells - microarray data
Cells are agarose embedded and cyclically compressed on FXC compression bioreactor for 4 hours followed by 24 hours of recovery incubation. RNA extracted according to Bougault et al (2008) and canine microarray performed -
"Increased Abundance of M cells in the Gut Epithelium Dramatically Enhances Oral Prion Disease Susceptibility"
Data supporting Donaldson et al "Increased Abundance of M cells in the Gut Epithelium Dramatically Enhances Oral Prion Disease Susceptibility" (In Submission). -
Data from the study "Fine-mapping host genetic variation underlying outcomes to Mycobacterium bovis infection in dairy cows"
This dataset derives form a study on the host genetic variation in resistance to bovine tuberculosis (bTB) in dairy cattle. It is well established that host genetic variation in resistance to bTB exists in dairy cattle. ... -
SUPERSEDED - Assembly of hundreds of microbial genomes from the cow rumen reveals novel microbial species encoding enzymes with roles in carbohydrate metabolism
## This item has been replaced by the one which can be found at https://doi.org/10.7488/ds/2296. ## The cow rumen is a specialised organ adapted for the efficient breakdown of plant material into energy and nutrients, ... -
Patchy promiscuity: machine learning applied to predict the host specificity of Salmonella enterica and Escherichia coli
Salmonella enterica and Escherichia coli are bacterial species that colonise different animal hosts with sub-types that can cause life-threatening infections in humans. Source attribution of zoonoses is an important goal ... -
A high resolution atlas of gene expression in the domestic sheep (Ovis aries)
Sheep are a key source of meat, milk and fibre for the global livestock sector, and an important biomedical model. Global analysis of gene expression across multiple tissues has aided genome annotation and supported ... -
An mRNA expression atlas for the domestic chicken generated by the meta-analysis of RNA-seq datasets
The chicken (Gallus gallus) is widely used as a model in developmental biology and is also an important livestock species. We have created an mRNA expression atlas for the domestic chicken spanning major tissue types and ... -
SUPERSEDED - Hi-C genomes from "Assembly of hundreds of microbial genomes from the cow rumen reveals novel microbial species encoding enzymes with roles in carbohydrate metabolism"
## This item has been replaced by the one which can be found at https://doi.org/10.7488/ds/2296. ## The cow rumen is a specialised organ adapted for the efficient breakdown of plant material into energy and nutrients, ... -
TMT generated proteomic identification and quantification of muscle and NMJ enriched fractions in mice and humans
The neuromuscular junction (NMJ) plays a fundamental role in transferring information from lower motor neurons to skeletal muscle to generate movement. It is also an experimentally-accessible model synapse routinely studied ... -
Proteomic analysis for peripherally accessible biomarkers in Neuronal Ceroid Lipofuscinosis (NCL)
iTRAQ and Label free Proteomic data generated from Skeletal muscle of CLN3 and PPT1 murine models of Batten disease. -
Assembly and validation of conserved long non-coding RNAs in the ruminant transcriptome
mRNA-like long non-coding RNAs (lncRNA) are a significant component of mammalian transcriptomes, although most are expressed only at low levels, with high tissue-specificity and/or at specific developmental stages. This ...
