Studies of DNA packaging and organisation in the regulation of genome activity and their impact on mutagenic and repair processes.
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ATAC-Seq reports local chromatin accessibility and provides a snapshot of active regulatory regions and genomic regions occupied by DNA-binding proteins in a given tissue. We used ATAC-Seq to identify open chromatin sites ...
Bidirectional transcription initiation marks accessible chromatin and is not specific to enhancers Enhancers are modular regulatory elements that are central to the spatial and temporal regulation of gene expression. Bidirectional transcription initiating at enhancers has been proposed to mark active enhancers and as ...