Infection and Immunity
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To enhance understanding of the mechanisms of host defence against infection, and translate this understanding into prevention and treatment.
Image: Detail from Fig1 of Lupolova et al. (2017) which uses data from Lupolova, Nadejda. (2017). Patchy promiscuity: machine learning applied to predict the host specificity of Salmonella enterica and Escherichia coli, [dataset]. University of Edinburgh. https://doi.org/10.7488/ds/2102.
Items in this Collection
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Antigenic diversity in Theileria parva populations from cattle and African buffalo analysed using long read sequencing
East Coast fever (ECF) in cattle is caused by the tick-borne protozoan Theileria parva, and is transmitted by the three-host tick Rhipicephalus appendiculatus. The African buffalo (Syncerus caffer) is the natural host for ... -
Staphylococcus aureus secreted lipases do not inhibit innate immune killing mechanisms: Extended Figure 1
Staphylococcus aureus pathogenesis is mediated by a plethora of secreted proteins, many of which remain incompletely characterised. For example, S. aureus abundantly secretes two isoforms of the enzyme lipase into the ... -
Data for "Pathogen transmission from vaccinated hosts can cause dose-dependent reduction in virulence"
# Abstract # Many livestock and increasingly human vaccines are leaky, blocking symptoms without preventing infection or onward transmission. Leakiness is concerning as it increases vaccination coverage required to ... -
SUPERSEDED - Data for "Transmission from vaccinated hosts can cause dose-dependent reduction in pathogen virulence"
## This item has been replaced by the one which can be found at https://doi.org/10.7488/ds/2725 . ## # Abstract # Many livestock and increasingly human vaccines are leaky, blocking symptoms without preventing infection ... -
Details of Staphylococcus spp. isolates used in a Staphylococcus aureus Host-Adaptation Study
A large-scale population genomic approach was used to provide a global perspective of the host-switching events that have defined the evolution of Staphylococcus aureus in the context of its host-species. To investigate ... -
Patchy promiscuity: machine learning applied to predict the host specificity of Salmonella enterica and Escherichia coli
Salmonella enterica and Escherichia coli are bacterial species that colonise different animal hosts with sub-types that can cause life-threatening infections in humans. Source attribution of zoonoses is an important goal ... -
Data from the study "Fine-mapping host genetic variation underlying outcomes to Mycobacterium bovis infection in dairy cows"
This dataset derives form a study on the host genetic variation in resistance to bovine tuberculosis (bTB) in dairy cattle. It is well established that host genetic variation in resistance to bTB exists in dairy cattle. ... -
RNA composition metrics
Mutating RNA virus genomes to alter codon pair (CP) frequencies and reduce translation efficiency has been advocated as a method to generate safe, attenuated virus vaccines. However, selection for disfavoured CPs leads to ...
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