Browsing Spires-Jones Laboratory by Title
Now showing items 4-17 of 17
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Image analysis macros for array tomography
The MATLAB and image J scripts provided here were used to analyse array tomography image stacks in the study "Reducing tau ameliorates behavioural and transcriptional deficits in a novel model of Alzheimer's disease" by ... -
An Investigation of Synaptic Dysfunction in Alzheimer’s Disease - Chapter 3 - Matlab Scripts
Alzheimer’s disease (AD) is characterized by the presence of aggregates of amyloid beta (Aβ) in senile plaques and tau in neurofibrillary tangles, as well as marked neuron and synapse loss. Of these pathological changes, ... -
An Investigation of Synaptic Dysfunction in Alzheimer’s Disease - Chapter 3 - Thresholding Macros
Alzheimer’s disease (AD) is characterized by the presence of aggregates of amyloid beta (Aβ) in senile plaques and tau in neurofibrillary tangles, as well as marked neuron and synapse loss. Of these pathological changes, ... -
An Investigation of Synaptic Dysfunction in Alzheimer’s Disease - Chapter 5 - Matlab Scripts
Alzheimer’s disease (AD) is characterized by the presence of aggregates of amyloid beta (Aβ) in senile plaques and tau in neurofibrillary tangles, as well as marked neuron and synapse loss. Of these pathological changes, ... -
An Investigation of Synaptic Dysfunction in Alzheimer’s Disease - Chapter 5 - Thresholding Macros
Alzheimer’s disease (AD) is characterized by the presence of aggregates of amyloid beta (Aβ) in senile plaques and tau in neurofibrillary tangles, as well as marked neuron and synapse loss. Of these pathological changes, ... -
An Investigation of Synaptic Dysfunction in Alzheimer’s Disease - Chapter 6 - Cell Profiler Pipeline
Alzheimer’s disease (AD) is characterized by the presence of aggregates of amyloid beta (Aβ) in senile plaques and tau in neurofibrillary tangles, as well as marked neuron and synapse loss. Of these pathological changes, ... -
An Investigation of Synaptic Dysfunction in Alzheimer’s Disease - Chapter 6 - Image J Macros
Alzheimer’s disease (AD) is characterized by the presence of aggregates of amyloid beta (Aβ) in senile plaques and tau in neurofibrillary tangles, as well as marked neuron and synapse loss. Of these pathological changes, ... -
Non-fibrillar oligomeric amyloid-β within synapses: Data set from publication Pickett et al 2016 J Alz Dis
Alzheimer’s disease (AD) is characterized by memory loss, insidious cognitive decline, profound neurodegeneration and the extracellular accumulation of amyloid-beta (Ab) peptide in senile plaques and intracellular accumulation ... -
Post-mortem brain analyses of the Lothian Birth Cohort 1936: Extending lifetime cognitive and brain phenotyping to the level of the synapse: Data set from publication Henstridge et al 2015 Acta Neuropath Comms
Non-pathological, age-related cognitive decline varies markedly between individuals and places significant financial and emotional strain on people, their families and society as a whole. Understanding the differential ... -
Region-specific depletion of synaptic mitochondria in the brains of patients with Alzheimer's disease - TEM data
Of all of the neuropathological changes observed in Alzheimer's disease (AD), the loss of synapses correlates most strongly with cognitive decline. The precise mechanisms of synapse degeneration in AD remain unclear, ... -
Research Plan - The effect of APOE genotype on microglial-mediated synapse loss in AD
This is a pre-registration of an experimental plan to examine the effect of APOE genotype on microglial-mediated synapse loss in Alzheimer's disease. There is now extensive literature covering synapse loss in AD and mouse ... -
Spread of tau down neural circuits precedes synapse and neuronal loss in the rTgTauEC mouse model of early Alzheimer’s disease - Data from 2017 Publication
This is the raw data associated with the manuscript Pickett et al (2017) Synapse. We provide the raw images and analysis files. Due to University of Edinburgh DataShare space constraints, we cannot upload the processed ... -
Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis - Analysis macros
In addition to motor neurone degeneration, up to 50% of Amyotrophic Lateral Sclerosis (ALS) patients present with cognitive decline. Understanding the neurobiological changes underlying these cognitive deficits is critical, ... -
Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis - Array tomography data
We provide the raw array tomography data that was analysed for the publication "Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis", published in Acta Neuropathologica ...
