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Depositordc.contributorGrant, Seth
Funderdc.contributor.otherEuropean Commissionen_UK
Funderdc.contributor.otherWellcome Trusten_UK
Data Creatordc.creatorQiu, Zhen
Data Creatordc.creatorKoniaris, Babis
Data Creatordc.creatorGrant, Seth
Citationdc.identifier.citationQiu, Zhen; Koniaris, Babis; Grant, Seth. (2018). Synaptome data with individual synapse parameters, types and subtypes across the 5 coronal mouse brain sections, [dataset].
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Dataset Description (abstract)dc.description.abstractSynapses are found in vast numbers in the brain and contain complex proteomes. We developed genetic labeling and imaging methods to examine synaptic proteins in individual excitatory synapses across all regions of the mouse brain. Synapse catalogs were generated from the molecular and morphological features of 0.5 billion synapses. Each synapse subtype showed a unique anatomical distribution and each brain region showed a distinct signature of synapse subtypes. Whole brain synaptome maps revealed spatial architecture from dendritic to global systems levels and previously unknown anatomical features. Synaptome mapping of circuits showed correspondence between synapse diversity and structural and functional connectomes. Behaviorally relevant patterns of neuronal activity trigger spatio-temporal postsynaptic responses sensitive to the structure of synaptome maps. Areas controlling higher cognitive function contain greatest synapse diversity and mutations causing cognitive disorders reorganized synaptome maps. Synaptome mapping technology and resources have wide application in studies of the normal and diseased brain.en_UK
Relation (Is Referenced By)dc.relation.isreferencedby
Relation (Is Referenced By)dc.relation.isreferencedbyZhu F et al. "Architecture of the Mouse Brain Synaptome" (2018) Neuron
Rightsdc.rightsCreative Commons Attribution 4.0 International Public Licenseen
Subjectdc.subjectSingle synapseen_UK
Subjectdc.subjectbrain anatomy
Subject Classificationdc.subject.classificationSubjects allied to Medicine::Neuroscienceen_UK
Titledc.titleSynaptome data with individual synapse parameters, types and subtypes across the 5 coronal mouse brain sectionsen_UK
Alternative Titledc.title.alternativeSynaptome architecture of the mouse brain reveals roles for synapse diversity in the connectome and in cognition.en_UK

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