Show simple item record

Depositordc.contributorGrant, Seth
Funderdc.contributor.otherEuropean Commissionen_UK
Funderdc.contributor.otherWellcome Trusten_UK
Data Creatordc.creatorQiu, Zhen
Data Creatordc.creatorKoniaris, Babis
Data Creatordc.creatorGrant, Seth
Date Accessioneddc.date.accessioned2018-06-21T15:23:48Z
Date Availabledc.date.available2018-08-06
Citationdc.identifier.citationQiu, Zhen; Koniaris, Babis; Grant, Seth. (2018). Synaptome data with individual synapse parameters, types and subtypes across the 5 coronal mouse brain sections, [dataset]. https://doi.org/10.7488/ds/2366en
Persistent Identifierdc.identifier.urihttps://hdl.handle.net/10283/3104
Persistent Identifierdc.identifier.urihttps://doi.org/10.7488/ds/2366
Dataset Description (abstract)dc.description.abstractSynapses are found in vast numbers in the brain and contain complex proteomes. We developed genetic labeling and imaging methods to examine synaptic proteins in individual excitatory synapses across all regions of the mouse brain. Synapse catalogs were generated from the molecular and morphological features of 0.5 billion synapses. Each synapse subtype showed a unique anatomical distribution and each brain region showed a distinct signature of synapse subtypes. Whole brain synaptome maps revealed spatial architecture from dendritic to global systems levels and previously unknown anatomical features. Synaptome mapping of circuits showed correspondence between synapse diversity and structural and functional connectomes. Behaviorally relevant patterns of neuronal activity trigger spatio-temporal postsynaptic responses sensitive to the structure of synaptome maps. Areas controlling higher cognitive function contain greatest synapse diversity and mutations causing cognitive disorders reorganized synaptome maps. Synaptome mapping technology and resources have wide application in studies of the normal and diseased brain.en_UK
Languagedc.language.isoengen_UK
Relation (Is Referenced By)dc.relation.isreferencedbyhttps://doi.org/10.1016/j.neuron.2018.07.007en_UK
Relation (Is Referenced By)dc.relation.isreferencedbyZhu F et al. "Architecture of the Mouse Brain Synaptome" (2018) Neuron https://doi.org/10.1016/j.neuron.2018.07.007
Rightsdc.rightsCreative Commons Attribution 4.0 International Public Licenseen
Subjectdc.subjectSingle synapseen_UK
Subjectdc.subjectPSD95
Subjectdc.subjectSAP102
Subjectdc.subjectbrain anatomy
Subject Classificationdc.subject.classificationSubjects allied to Medicine::Neuroscienceen_UK
Titledc.titleSynaptome data with individual synapse parameters, types and subtypes across the 5 coronal mouse brain sectionsen_UK
Alternative Titledc.title.alternativeSynaptome architecture of the mouse brain reveals roles for synapse diversity in the connectome and in cognition.en_UK
Typedc.typedataseten_UK

Download All
zip file MD5 Checksum: 5771cccd315a3096f9b96f0ba778aa67

Files in this item

Thumbnail
Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record