Reece Lab
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The lab is interested in uncovering the strategies parasites have evolved to cope with the challenges and opportunities of their lifestyle.
Items in this Collection
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Mistimed malaria parasites re-synchronise with host feeding-fasting rhythms by shortening their intra-erythrocytic development duration.
Malaria parasites exhibit daily rhythms in the intraerythrocytic development cycle (IDC) that underpins asexual replication in the blood. The IDC schedule is aligned with the timing of host feeding-fasting rhythms. When ... -
Daily rhythms of both host and parasite affect antimalarial drug efficacy
Circadian rhythms contribute to treatment efficacy in several non-communicable diseases. However, chronotherapy (administering drugs at a particular time-of-day) against infectious diseases has been overlooked. Yet, the ... -
The ecology of asynchronous asexual replication: Plasmodium berghei’s intraerythrocytic development cycle is resistant to host rhythms
Daily periodicity in the diverse activities of parasites occurs across a broad taxonomic range. The rhythms exhibited by parasites are thought to be adaptations that allow parasites to cope with, or exploit, the consequences ... -
Host circadian clocks do not set the schedule for the within-host replication of malaria parasites
Circadian clocks coordinate organisms' activities with daily cycles in their environment. Parasites are subject to daily rhythms in the within-host environment, resulting from clock-control of host activities, including ... -
Data from: Adaptive phenotypic plasticity in malaria parasites is not constrained by previous responses to environmental change.
Infection dynamics data for P. chabaudi parasites in treatment groups that include parasites in mice treated with 30mg/kg phenylhydrazine (“PHZ”), parasites in untreated mice (“Control”), or parasites currently in untreated ... -
Time-of-day of blood feeding: effects on mosquito life history and malaria transmission
Biological rhythms allow organisms to compartmentalise and coordinate aspects of their life with the predictable daily rhythms of their environment. There is increasing recognition that understanding the biological rhythms ... -
Data from: Evolutionary sex allocation theory explains sex ratios in natural Plasmodium falciparum infections.
Male and female gametocyte counts forming the basis of the sex ratio analysis of P. falciparum parasites in natural infections. -
Adaptive plasticity in the gametocyte conversion rate of malaria parasites
Malaria parasites in the host replicate asexually and, during each replication cycle, some asexuals transform into sexual stages that enable between-host transmission. It is not understood why the rate of conversion to ...
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