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Depositordc.contributorSchneider, Petra
Funderdc.contributor.otherBBSRC - Biotechnology and Biological Sciences Research Councilen_UK
Funderdc.contributor.otherNERC - Natural Environment Research Councilen_UK
Funderdc.contributor.otherThe Royal Societyen_UK
Funderdc.contributor.otherWellcome Trusten_UK
Funderdc.contributor.otherHFSP - Human Frontier Science Programen_UK
Funderdc.contributor.otherFNR of Luxembourgen_UK
Funderdc.contributor.otherNatural Sciences and Engineering Research Council of Canadaen_UK
Data Creatordc.creatorSchneider, Petra
Data Creatordc.creatorGreischar, Megan A
Data Creatordc.creatorBirget, Philip LG
Data Creatordc.creatorRepton, Charlotte
Data Creatordc.creatorMideo, Nicole
Data Creatordc.creatorReece, Sarah E
Citationdc.identifier.citationSchneider, Petra; Greischar, Megan A; Birget, Philip L G; Repton, Charlotte; Mideo, Nicole; Reece, Sarah E. (2018). Adaptive plasticity in the gametocyte conversion rate of malaria parasites, [dataset]. University of Edinburgh.
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Dataset Description (abstract)dc.description.abstractMalaria parasites in the host replicate asexually and, during each replication cycle, some asexuals transform into sexual stages that enable between-host transmission. It is not understood why the rate of conversion to sexual stages varies during infections despite its importance for the severity and spread of the disease. We combined a mathematical model and experiments to show that parasites adjust conversion rates depending on changes in their in-host population size. When population sizes plummet, between-host transmission is prioritised. However, smaller losses in number elicit reproductive restraint, which facilitates in-host survival and future transmission. We show that increased and decreased conversion in response to a range of in-host environments are actually part of one continuum: a sophisticated reproductive strategy similar to that of multicellular organisms.en_UK
Publisherdc.publisherUniversity of Edinburghen_UK
Relation (Is Referenced By)dc.relation.isreferencedbySchneider, PLoS Pathogens 2018 (accepted)en_UK
Rightsdc.rightsCreative Commons Attribution 4.0 International Public Licenseen
Subjectdc.subjectlife history theoryen_UK
Subjectdc.subjectresource allocation trade offen_UK
Subjectdc.subjectphenotypic plasticityen_UK
Subject Classificationdc.subject.classificationBiological Sciences::Parasitologyen_UK
Titledc.titleAdaptive plasticity in the gametocyte conversion rate of malaria parasitesen_UK

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