PiW
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Positron Emission Tomography (PET) is an imaging technique that relies on the injection of a molecule that has been specifically designed so that it binds to a targeted receptor, transporter, enzyme or protein in the body, i.e. a radiotracer. PET can be coupled with Computed Tomography (CT) or Magnetic Resonance (MR) imaging to provide anatomical landmarks and better describe regional distribution of the PET radiotracer in vivo.
PET is a powerful tool used to improve the understanding of how human diseases develop and progress, to discover new treatments for disease and ultimately to make a real impact on people’s health. A PET image is the perfect union of the wonders of physics (radioactive decay and positron annihilation), chemistry (uniquely tailored compounds), biology (multidimensional complex processes happening in real time) and mathematics (multiparametric kinetic data). It is a technique full of wonder and able to unlock the wonders of human physiology and pathophysiology.
PET is Wonderful (PiW) is also the name of an ever-expanding team of committed researchers led by Dr Adriana Tavares, and a series of international meetings designed to bring together the wider PET imaging community.
This DataShare Collection contains previously published data from the Tavares group, including raw PET and CT datasets, so that everyone can explore, expand and enjoy the wonders of PET science.
Items in this Collection
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Quantification of Macrophage-Driven Inflammation During Myocardial Infarction with 18F-LW223, a Novel TSPO Radiotracer with Binding Independent of the rs6971 Human Polymorphism
Myocardial infarction (MI) is one of the leading causes of death worldwide, and inflammation is central to tissue response and patient outcomes. The 18-kDa translocator protein (TSPO) has been used in PET as an inflammatory ... -
Effects of administration route on uptake kinetics of 18F‑sodium fluoride positron emission tomography in mice
18F-sodium fluoride (18F-NaF) is a positron emission tomography (PET) radiotracer widely used in skeletal imaging and has also been proposed as a biomarker of active calcification in atherosclerosis. Like most PET radiotracers, ... -
A Systems-Level Analysis of Total-Body PET Data Reveals Complex Skeletal Metabolism Networks in vivo
Bone is now regarded to be a key regulator of a number of metabolic processes, in addition to the regulation of mineral metabolism. However, our understanding of complex bone metabolic interactions at a systems level ... -
PET Imaging experimental dataset - Victoria Morley
Data generated by Victoria Morley as part of her PhD research -
Average male and female mouse brain TSPO atlases, generated using TSPO PET radiotracer [18F]LW223 (normalised to injected dose)
[18F]LW223 is a novel Positron Emission Tomography (PET) radiotracer which can be used to detetect 18kDa translocator protein (TSPO) distribution in vivo. Murine brain TSPO atlases were generated using average SUV at 90-120 ... -
SUPERSEDED - Average male, female and mixed gender mouse TSPO brain maps, generated using TSPO PET radiotracer [18F]LW223 (unnormalized to injected dose)
## This item has been replaced by the one which can be found at https://doi.org/10.7488/ds/2988 ## [18F]LW223 is a novel Positron Emission Tomography (PET) radiotracer which can be used to detetect 18kDa translocator ... -
Additional image (Fig 2) - Kinetic modelling and quantification bias in small animal PET studies with [18F]AB5186, a novel 18 kDa translocator protein radiotracer
This image is part of the dataset: MacAskill, Mark. (2020). Kinetic modelling and quantification bias in small animal PET studies with [18F]AB5186, a novel 18 kDa translocator protein radiotracer, [image]. University of ... -
Kinetic modelling and quantification bias in small animal PET studies with [18F]AB5186, a novel 18 kDa translocator protein radiotracer
DICOM imaging data sets, CT and PET. Distribution and kinetics of [18F]AB5186 in rats. Please note one of the images is in a separate Item in this repository, please see: MacAskill, Mark. (2020). Additional image (Fig 2) ... -
CT Image datasets for highdose 16A0XXX and 16A1XXX
High dose microCT does not contribute towards improved microPET/CT image quantitative accuracy and can limit longitudinal scanning of small animals ABSTRACT Obtaining accurate quantitative measurements in preclinical ... -
CT Image datasets for highdose 16A2XXX and 16A3XXX
High dose microCT does not contribute towards improved microPET/CT image quantitative accuracy and can limit longitudinal scanning of small animals ABSTRACT Obtaining accurate quantitative measurements in preclinical ...