Fibre-based Fluorescence Lung Imaging
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Lung diseases, such as asthma, acute respiratory infections, tuberculosis, lung cancer, and chronic obstructive pulmonary disease (COPD), are a global concern. More than one billion people suffer from either acute or chronic respiratory conditions worldwide. Better understanding of lung disease is crucial to reducing morbidity and mortality. Fluorescence-based optical endomicroscopy (OEM) systems, enabled with fibre bundles, have stimulated interest within this area because they provide a low cost and minimally invasive solution for high resolution imaging and measurements in vivo, in situ.
Image: Tanner, Michael G. (2019). Data and code for: High fidelity fibre-based physiological sensing deep in tissue, [dataset]. University of Edinburgh. https://datashare.is.ed.ac.uk/handle/10283/3325
Items in this Collection
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Data for publication "Deep Learning-Assisted Co-registration of Full-Spectral Autofluorescence Lifetime Microscopic Images with H&E-Stained Histology Images"
This dataset contains partial data underlying figure 2 (first 2 rows), 3 and 5 in "Deep Learning-Assisted Co-registration of Full-Spectral Autofluorescence Lifetime Microscopic Images with H&E-Stained Histology Images". ... -
Autofluorescence lifetime endomicroscopic images on ex-vivo lung cancer
This dataset contains the data for the publication of "A Layer-Level Multi-Scale Architecture for Lung Cancer Classification with Fluorescence Lifetime Imaging Endomicroscopy". This was collected by a custom-built dual-band ... -
Data for publication "Full spectral fluorescence lifetime Imaging with 0.5 nm spectral and 50 ps temporal resolution"
This dataset contains the data underlying the figure 2-5 of the paper "Full spectral fluorescence lifetime imaging with 0.5 nm spectral and 50 ps temporal resolution". The datafiles contain the data for full spectral ... -
Red-shifted environmental fluorophores and their use for the detection of Gram-negative bacteria_raw spectral data
Spectral data (absorption, fluorescence, lifetime) of merocyanine derivatives described in the research article entitled "Red-shifted environmental fluorophores and their use for the detection of Gram-negative bacteria" ... -
Source code and example data for "Open source image processing methods for real-time fibre bundle optical endomicroscopy"
The dataset contains source code in C++ (with OpenCV) and MATLAB (with Image Processing Toolbox) to process images acquired by Optical Endomicroscopy (OEM) with imaging fibre bundles. Example images of human and porcine ... -
Data and code for Core crosstalk in ordered imaging fibre bundles
Data and code for the paper: "Core crosstalk in ordered imaging fibre bundles" Parker, H, et al. (Accepted manuscript). -
Supplementary material for paper "Time-resolved spectroscopy of fluorescence quenching in optical fibre-based pH sensors"
Abstract: Numerous optodes, with fluorophores as the chemical sensing element and optical fibres for light delivery and collection, have been fabricated for minimally invasive endoscopic measurements of key physiological ... -
Exploratory use of fluorescent SmartProbes for the rapid detection of microbial isolates causing corneal ulcer
# Purpose # To explore the use of optical SmartProbes for the rapid evaluation of corneal scrapes from patients with suspected microbial keratitis, as a clinical alternative to Gram stain. # Design # Experimental ... -
Molecular Detection of Gram-positive Bacteria in the Human Lung through an Optical Fiber Based Endoscope
# Purpose # The relentless rise in antimicrobial resistance is a major societal challenge and requires, as part of its solution, a better understanding of bacterial colonization and infection. To facilitate this, we ... -
Frugal filtering optical lenses for point-of-care diagnostics
Abstract: Infectious diseases are the leading cause of morbidity and mortality in low and middle income countries (LMICs). Rapid diagnosis of infections in LMICs presents many challenges especially in rural areas where ... -
Circuits! - Demonstrating the use of optical fibres in biomedical sciences
The Circuits! - project, funded through the The Royal Academy of Engineering Ingenious Grant (ING1617/11/114), demonstrates how research at the intersection of physics, engineering, biology, and medicine can be presented ... -
Data and code for: High fidelity fibre-based physiological sensing deep in tissue
Physiological sensing deep in tissue, remains a clinical challenge. Here a flexible miniaturised sensing optrode providing a platform to perform minimally invasive in vivo in situ measurements is reported. Silica microspheres ... -
Data and Code for "Fibre-based Spectral Ratio Endomicroscopy for Contrast Enhancement of Bacterial Imaging and Pulmonary Autofluorescence"
Fibre-based optical endomicroscopy (OEM) permits high resolution fluorescence microscopy in endoscopically accessible tissues. Fibred OEM has the potential to visualise pathologies targeted with fluorescent imaging probes ...
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