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Depositordc.contributorBailey, Richard
Funderdc.contributor.otherUSDA - United States Department of Agricultureen_UK
Data Creatordc.creatorDunn, John R
Data Creatordc.creatorCheng, Hans H
Data Creatordc.creatorDoeschl-Wilson, Andrea
Data Creatordc.creatorBailey, Richard I
Data Creatordc.creatorChase-Topping, Margo
Data Creatordc.creatorMays, Jody
Data Creatordc.creatorAnacleto, Osvaldo
Date Accessioneddc.date.accessioned2019-08-05T12:09:26Z
Date Availabledc.date.available2020-06-30T04:15:10Z
Citationdc.identifier.citationDunn, John R; Cheng, Hans H; Doeschl-Wilson, Andrea; Bailey, Richard I; Chase-Topping, Margo; Mays, Jody; Anacleto, Osvaldo. (2020). SUPERSEDED - Data for "Transmission from vaccinated hosts can cause dose-dependent reduction in pathogen virulence", [dataset]. University of Edinburgh. https://doi.org/10.7488/ds/2598.en
Persistent Identifierdc.identifier.urihttps://hdl.handle.net/10283/3386
Persistent Identifierdc.identifier.urihttps://doi.org/10.7488/ds/2598
Dataset Description (abstract)dc.description.abstract## This item has been replaced by the one which can be found at https://doi.org/10.7488/ds/2725 . ## # Abstract # Many livestock and increasingly human vaccines are leaky, blocking symptoms without preventing infection or onward transmission. Leakiness is concerning as it increases vaccination coverage required to prevent disease spread, and can promote evolution of increased pathogen virulence. Despite leakiness, vaccination may reduce pathogen load, affecting disease transmission dynamics. However, the impacts on post-transmission disease development and infectiousness in contact individuals are unknown. Here, we use transmission experiments involving Marek’s disease virus in chickens to show that vaccination with a leaky vaccine substantially reduces viral load in both vaccinated individuals and unvaccinated contact individuals they infect. Consequently, contact birds are less likely to develop disease symptoms or die, show less severe symptoms when these are present, and shed less infectious virus themselves, when infected by vaccinated birds. These results highlight that even partial vaccination with a leaky vaccine can have unforeseen positive consequences in controlling the spread and symptoms of disease.en_UK
Dataset Description (TOC)dc.description.tableofcontentsData descriptions are all in the file "MD analysis data filtering details.R". Names of all files: * "MD analysis data filtering details.R " * "ContactMort_2018.csv " * "Shedder_2018.csv " * "ContactDiseaseSEM_2018.csv " * "ContactDiseaseS_2018.csv " * "Contact_2018.csv " * "ContactInfection_2018.csv " * "ViralLoadFile_2017_2018.csv"en_UK
Languagedc.language.isoengen_UK
Publisherdc.publisherUniversity of Edinburghen_UK
Relation (Is Referenced By)dc.relation.isreferencedbyBailey et al. "Transmission from vaccinated hosts can cause dose-dependent reduction in pathogen virulence" (In submission)en_UK
Superseded Bydc.relation.isreplacedbyhttps://doi.org/10.7488/ds/2725
Rightsdc.rightsCreative Commons Attribution 4.0 International Public Licenseen
Subject Classificationdc.subject.classificationVeterinary Sciences Agriculture and related subjectsen_UK
Titledc.titleSUPERSEDED - Data for "Transmission from vaccinated hosts can cause dose-dependent reduction in pathogen virulence"en_UK
Typedc.typedataseten_UK

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