Usher Institute
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The Usher Institute is a high-energy, interdisciplinary environment dedicated to improving the health of individuals and populations locally and globally through research, innovation, knowledge exchange and education.
The Usher Institute sits within the Edinburgh Medical School. It has 4 core research centres, hosts the Edinburgh Clinical Trials Unit, and is a delivery hub within the Data-Driven Innovation Programme of the Edinburgh and South East Scotland City Region Deal
www.ed.ac.uk/usherCollections in this community
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RESPIRE
NIHR Global Health Research Unit on Respiratory Health (RESPIRE)
Recent Submissions
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Polygenic risk scores and GWAS summary statistics for an analysis of the contribution of common risk variants to multiple sclerosis in Orkney and Shetland
Orkney and Shetland, the population isolates which make up the Northern Isles of Scotland, are of particular interest to multiple sclerosis (MS) research. While MS prevalence is high in Scotland, Orkney has the highest ... -
Large scale phenotype imputation and in vivo functional validation implicate ADAMTS14 as a novel adiposity gene - Supplementary data
Obesity remains an unmet global health burden. Detrimental anatomical distribution of body fat is a major driver of obesity-mediated mortality risk and is demonstrably heritable. However, our understanding of the full ... -
Medication-Wide Association Study of Dementia
Dataset and code list from medication-wide association study of dementia, using the Secure Anonymised Information Linkage databank Dementia electronic Cohort (SAIL-DeC). The dataset contains the hazard ratios and p-values ... -
"The genetic underpinnings of adiposity: from GWAS discovery to functional characterisation" extended supplementary data
Two extended supplementary tables, needed for the submission of a thesis in fulfilment of a PhD in Precision Medicine at the University of Edinburgh in 2020. This upload includes 2 files. The first file ("TableS1_iDXA_ ... -
Dementia risk prediction model - definitions of variables
List of ICD-10 and Read version 2 codes used to define predictor and outcome variables for dementia risk prediction model. -
Multivariate genomic scan implicates novel loci and haem metabolism in human ageing
Ageing phenotypes, such as years lived in good health (healthspan), total years lived (lifespan), and survival until an exceptional old age (longevity), are of interest to us all but require exceptionally large sample sizes ... -
SUPERSEDED - Medication-wide association study of dementia
## This item has been replaced by the one which can be found at https://datashare.is.ed.ac.uk/handle/10283/3792 ## Dataset from medication-wide association study of dementia, using the Secure Anonymised Information Linkage ... -
A nation-wide retrospective, data-linkage, cohort study of epilepsy and incident dementia - supplement
Supplement to publication in Neurology. The text file holds two lists of codes used in electronic health records (hospital admission, death (ICD 10) and GP admission (ReadV2)) to classify dementia (incl. subtypes) and epilepsy. -
Phase 2: The views and experiences of people with limited health literacy and asthma on managing their condition: a qualitative study
We used a method called photovoice, an arts-based qualitative method by which people can identify, represent and express their life experience through photographs. The photographs were used to stimulate discussion during ... -
Optical Coherence Tomography Angiography retinal scans and segmentations
Optical Coherence Tomography Angiography retinal scans from 11 participants in the PREVENT study and associated manual segmentations of the vasculature in the scans. Optical coherence tomography angiography (OCTA) is ... -
SAIL dementia e-cohort (SAIL-DeC)
These files contain details on the creation of the Secure Anonymised Information Linkage (SAIL) databank dementia e-cohort (SAIL-DeC). -
Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances
We use a genome-wide association of 1 million parental lifespans of genotyped subjects and data on mortality risk factors to validate previously unreplicated findings near CDKN2B-AS1, ATXN2/BRAP, FURIN/FES, ZW10, PSORS1C3, ... -
Epidemiological characteristics of human-infective RNA viruses
RNA viruses are a major threat to human health. Here, based on extensive literature searches carried out over a period of 18 years, we provide a catalogue of all 214 known human-infective RNA virus species. We link these ... -
SUPERSEDED - Epidemiological characteristics of human-infective RNA viruses
## This data item has been replaced by the one which can be found at https://doi.org/10.7488/ds/2265 . ## RNA viruses are a major threat to human health. Here, based on extensive literature searches carried out over a ... -
SUPERSEDED - Epidemiological characteristics of human-infective RNA viruses
## This item has been superseded by the one which can be found at https://doi.org/10.7488/ds/2265 . ## RNA viruses are a major threat to human health. Here, based on extensive literature searches carried out over a period ... -
Data extraction sheet for the systematic review of VARI-PD
Pneumococcal disease (PD) is a major cause of communicable disease burden globally. Evidence from animal and in vitro studies suggest viral acute respiratory infection (VARI) can predispose to pneumococcal infection. ... -
Data supporting Rubio et al on exacerbations of COPD
Please see the publication Rubio et al. ('Home monitoring of breathing rate in people with Chronic Obstructive Pulmonary Disease: observational study of feasibility, acceptability and change after exacerbation' International ... -
SUPERSEDED - Data supporting Rubio et al on exacerbations of COPD
## This dataset has been replaced by the one at https://doi.org/10.7488/ds/1981 . ##
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