Organ Fibrosis and Regeneration
Organ fibrosis (scarring) is a major cause of morbidity and mortality worldwide, and as yet there are no effective anti-fibrotic treatments. Research groups at the Centre for Inflammation Research are interested in the cellular and molecular mechanisms that drive organ fibrosis, and also the molecular pathways which are responsible for efficient wound healing and healthy tissue regeneration following injury. By understanding more about how organs scar, heal and regenerate they hope to develop new treatments for patients with fibrotic diseases.
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Single-cell transcriptomics uncovers zonation of function in the mesenchyme during liver fibrosis - Seurat objects We profile the transcriptomes of ~30,000 mouse single cells to deconvolve the hepatic mesenchyme in healthy and fibrotic liver at high resolution. We reveal spatial zonation of hepatic stellate cells across the liver lobule, ...
We profile the transcriptomes of non-parenchymal cell types present in healthy and cirrhotic human liver. In particular, we uncover a novel scar-associated TREM2+CD9+ macrophage subpopulation, which expands in liver fibrosis, ...