Genome-wide association studies identify 137 loci for DNA methylation biomarkers of aging

McCartney, Daniel; Min, Josine; Richmond, Rebecca; Lu, Ake; Sobczyk, Maria; Davies, Gail; Broer, Linda; Guo, Xiuqing; Jeong, Ayoung; Jung, Jeeson; Kasela, Silva; Katrinli, Seyma; Kuo, Pei-Lun; Matias-Garcia, Pamela; Mishra, Pashupati; Nygaard, Marianne; Palviainen, Teemu; Patki, Amit; Raffield, Laura; Ratliff, Scott; Richardson, Tom; Robinson, Oliver; Sorensen, Mette; Sun, Dianjianyi; Tsai, Pei-Chien; van der Zee, Matthijs; Wang, Xiaochuan; Wang, Yunzhang; Xia, Rui; Xu, Zongli; Yao, Jie; Zhao, Wei; Deary, Ian; Relton, Caroline; Horvath, Steve; Marioni, Riccardo

Date Available

2020-07-01

Type

dataset

Data Creator

McCartney, Daniel
Min, Josine
Richmond, Rebecca
Lu, Ake
Sobczyk, Maria
Davies, Gail
Broer, Linda
Guo, Xiuqing
Jeong, Ayoung
Jung, Jeeson
Kasela, Silva
Katrinli, Seyma
Kuo, Pei-Lun
Matias-Garcia, Pamela
Mishra, Pashupati
Nygaard, Marianne
Palviainen, Teemu
Patki, Amit
Raffield, Laura
Ratliff, Scott
Richardson, Tom
Robinson, Oliver
Sorensen, Mette
Sun, Dianjianyi
Tsai, Pei-Chien
van der Zee, Matthijs
Wang, Xiaochuan
Wang, Yunzhang
Xia, Rui
Xu, Zongli
Yao, Jie
Zhao, Wei
Deary, Ian
Relton, Caroline
Horvath, Steve
Marioni, Riccardo

Publisher

University of Edinburgh. Centre for Cognitive Ageing and Cognitive Epidemiology

Relation (Is Referenced By)

https://www.biorxiv.org/content/10.1101/2020.06.29.133702v1

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Citation

McCartney, Daniel; Min, Josine; Richmond, Rebecca; Lu, Ake; Sobczyk, Maria; Davies, Gail; Broer, Linda; Guo, Xiuqing; Jeong, Ayoung; Jung, Jeeson; Kasela, Silva; Katrinli, Seyma; Kuo, Pei-Lun; Matias-Garcia, Pamela; Mishra, Pashupati; Nygaard, Marianne; Palviainen, Teemu; Patki, Amit; Raffield, Laura; Ratliff, Scott; Richardson, Tom; Robinson, Oliver; Sorensen, Mette; Sun, Dianjianyi; Tsai, Pei-Chien; van der Zee, Matthijs; Wang, Xiaochuan; Wang, Yunzhang; Xia, Rui; Xu, Zongli; Yao, Jie; Zhao, Wei; Deary, Ian; Relton, Caroline; Horvath, Steve; Marioni, Riccardo. (2020). Genome-wide association studies identify 137 loci for DNA methylation biomarkers of aging, [dataset]. University of Edinburgh. Centre for Cognitive Ageing and Cognitive Epidemiology. https://doi.org/10.7488/ds/2834

Description

These files contain summary statistics for meta-analysis GWAS of six traits in European, African and Trans-Ancestry. There are 18 files in total - 6 for each ancestry by 3 for each trait. The traits are DNA methylation proxies for granulocyte proportions (gran) and plasminogen activator inhibitor-1 (PAI1), and four epigenetic age acceleration measures of: PhenoAge, GrimAge, HannumAge, and Intrinsic Epigenetic Age Acceleration (IEAA).