We study the mechanisms used to segregate chromosomes during cell division. Errors in chromosome segregation result in aneuploidy, a condition in which cells have too few or too many chromosomes and which is associated with birth defects, such as Down's syndrome, infertility and cancer. Our approach is to use budding yeast, fission yeast and frog eggs together with a powerful combination of genetics, cell biology and biochemistry to dissect the fundamental pathways that control chromosome segregation and which have been largely conserved in eukaryotes.

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