Browsing Genetic Variation by Date Accessioned
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GenomeArtiFinder variant include list
Background: The loss of genetic diversity in segments over a genome (loss-of-heterozygosity, LOH) is a common occurrence in many types of cancer. By analysing patterns of preferential allelic retention during LOH in ... -
Pervasive lesion segregation shapes cancer genome evolution
Cancers arise through the acquisition of oncogenic mutations and grow by clonal expansion. Here we reveal that most mutagenic DNA lesions are not resolved into a mutated DNA base pair within a single cell cycle. Instead, ...