Our aim is to reveal how neuronal networks integrate visual information to guide perceptions and actions. We use the mouse primary visual cortex as a model system of cortical integration of sensory and non-sensory information.
By using two-photon calcium imaging combined with electrophysiological recordings in awake behaving mice, our current projects investigate:
- How visually-guided behaviour modulates neuronal activity in the visual cortex
- How individual pyramidal neurons integrate feed-forward visual inputs with contextual inputs
- How cortical information processing is impacted by metabolic state
Using such information, we apply the same combination of methods to study how this network activity is disrupted in the brain of mouse models for autistic spectrum disorders and intellectual disabilities.
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Items in this Collection
Information processing is energetically expensive. In the mammalian brain, it is unclear how information coding and energy use are regulated during food scarcity. Using whole-cell recordings and two-photon imaging in layer ...
High and asymmetric somato-dendritic coupling of V1 layer 5 neurons independent of visual stimulation and locomotion Ex vivo calibration of GCaMP6s and GCaMP6f signals in soma and apical tuft dendrites of layer 5 pyramidal neurons from the mouse primary visual cortex (V1). We examined the relationship between neuronal spiking and calcium ...