El Karoui Lab
One of the most fundamental questions in biology is how cells replicate, repair and segregate chromosomes, and how failures in those processes result in mutations, genome rearrangements or cell death. In bacteria, many clinically relevant antibiotics target DNA replication and repair which in turn often promotes mutagenesis and recombination leading to drug resistance. The El Karoui Lab works to explore the contribution of molecular stochasticity to genetic variability in E. coli in the physiological context of the cell. Our approach may be broadly summarised as Bacterial Systems Biology.
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In natural environments bacteria are frequently exposed to sub-lethal levels of DNA damage which leads to the induction of a stress response (the SOS response in Escherichia coli). Natural environments also vary in nutrient ...