Centre for Discovery Brain Sciences
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The centre carries our research on fundamental physiological mechanisms and pathways, from single genes to complex behaviour, relevant to normal human function and how disruption of these mechanisms lead to disease.
Centre for Discovery Brain Sciences
Image: CC-BY Jones RA, Gillingwater TH https://doi.org/10.7488/ds/1490
Sub-communities within this community
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Richard Ribchester Research Group
Neuromuscular connections
Collections in this community
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Davies Laboratory
Prof Jamie Davies' research on developmental biology -
Gillingwater Laboratory
Neuroscience -
Nolan Lab
Data from the lab of Prof Matt Nolan -
Spires-Jones Laboratory
Degenerative brain diseases and ageing -
UK Dementia Research Institute
UK DRI at the University of Edinburgh
Recent Submissions
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Grid cells are modulated by local head direction
In vivo tetrode recordings from the medial entorhinal cortex of mice during open field exploration. This data set contains recordings from grid cells, conjunctive cells and other spatial cells. Please look at Gerlei_et_a ... -
APP NL/F - 1 year rodent EEG and video recordings. Cerebellum reference
This dataset relates to the rodent data reported in the manuscript "Circadian and brain state modulation of network hyperexcitability in Alzheimer's disease". (Brown et al., (2018) 27 April 2018, 5 (2) ENEURO.0426-17.2018. ... -
APP NL/F - 8 month rodent EEG and video recordings
This dataset relates to the rodent data reported in the manuscript "Circadian and brain state modulation of network hyperexcitability in Alzheimer's disease". (Brown et al., (2018) 27 April 2018, 5 (2) ENEURO.0426-17.2018. ... -
APP NL/F - 1 year rodent EEG and video recordings. Cerebellum reference. Donepezil administration
This dataset relates to the rodent data reported in the manuscript "Circadian and brain state modulation of network hyperexcitability in Alzheimer's disease". (Brown et al., (2018) 27 April 2018, 5 (2) ENEURO.0426-17.2018. ... -
J20 rodent EEG and video recordings
This dataset relates to the rodent data reported in the manuscript "Circadian and brain state modulation of network hyperexcitability in Alzheimer's disease". (Brown et al., (2018) 27 April 2018, 5 (2) ENEURO.0426-17.2018. ... -
APP NL/F - 1 year rodent EEG and video recordings. Cortex reference
This dataset relates to the rodent data reported in the manuscript "Circadian and brain state modulation of network hyperexcitability in Alzheimer's disease". (Brown et al., (2018) 27 April 2018, 5 (2) ENEURO.0426-17.2018. ... -
Motyl AAL, et al. (2020). Pre-symptomatic developmental phenotypes in Spinal Muscular Atrophy
Spinal muscular atrophy (SMA) is a leading genetic cause of infant death, characterised primarily by a loss of lower motor neurons. SMA is caused by mutations in the survival motor neuron 1 (SMN1) gene. New SMN-restoring ... -
Inter- and intra-animal variation in the integrative properties of stellate cells in the medial entorhinal cortex
The data are whole-cell patch-clamp recordings from neurons in the medial entorhinal cortex of adult mice. The data for each neuron is a series of voltage responses to current steps or ramps injected through the recording ... -
Systematic Review of the Literature on Definitions and Characterisation of MS Lesions
While inspecting the brain magnetic resonance imaging (MRI) scans from a sample of Multiple Sclerosis (MS) patients, blind to any clinical, cognitive and demographic information, it caught our attention the presence of ... -
Brain Network Measures and Spatial Lesion Distribution in a Sample of 47 Patients with Systemic Lupus Erythematosus (SLE)
This dataset corresponds to a research on network organisation of brain structural connectivity in systemic lupus erythematosus (SLE) and its putative association with lesion distribution and disease indicators. White ... -
Fan cells in layer 2 of lateral entorhinal cortex are critical for episodic-like memory
Episodic memory requires different types of information to be bound together to generate representations of experiences. The lateral entorhinal cortex (LEC) and hippocampus are required for episodic-like memory in rodents. ... -
Interleukin-1 receptor antagonist treatment in acute ischaemic stroke does not alter systemic markers of anti-microbial defence
Background: Blockade of the cytokine interleukin-1 (IL-1) with IL-1 receptor antagonist (IL-1Ra) is a candidate treatment for stroke entering phase II/III trials, which acts by inhibiting harmful inflammatory responses. ... -
aNMJ-morph macro
It is recommended that users of the aNMJ-morph macro are familiar with the original NMJ-morph workflow in a practical setting; please refer to the following publication for background details: "NMJ-morph reveals principal ... -
Image analysis macros for array tomography
The MATLAB and image J scripts provided here were used to analyse array tomography image stacks in the study "Reducing tau ameliorates behavioural and transcriptional deficits in a novel model of Alzheimer's disease" by ... -
SUPERSEDED - Interleukin-1 receptor antagonist treatment in acute ischaemic stroke does not alter systemic markers of anti-microbial defence
## This item has been replaced by the one which can be found at https://doi.org/10.7488/ds/2626 ## Background: Blockade of the cytokine interleukin-1 (IL-1) with IL-1 receptor antagonist (IL-1Ra) is a candidate treatment ... -
SUPERSEDED - Interleukin-1 receptor antagonist treatment in acute ischaemic stroke does not alter systemic markers of anti-microbial defence
## This item has been replaced by the one which can be found at http://hdl.handle.net/10283/3354 ## Full datasets for all figures in the manuscript "Interleukin-1 receptor antagonist treatment in acute ischaemic stroke ... -
SUPERSEDED - Supplementary Figures: Interleukin-1 receptor antagonist treatment in acute ischaemic stroke does not alter systemic markers of anti-microbial defence
## This item has been replaced by the one which can be found at https://doi.org/10.7488/ds/2626 ## Supplementary Figures from the manuscript "Interleukin-1 receptor antagonist treatment in acute ischaemic stroke does not ... -
Region-specific depletion of synaptic mitochondria in the brains of patients with Alzheimer's disease - TEM data
Of all of the neuropathological changes observed in Alzheimer's disease (AD), the loss of synapses correlates most strongly with cognitive decline. The precise mechanisms of synapse degeneration in AD remain unclear, ... -
Thesis Movies - 'Mechanisms of kidney vascularisation and the roles of macrophages in renal organogenesis'
Movies for the doctoral thesis 'Mechanisms of kidney vascularisation and the roles of macrophages in renal organogenesis'. -
Proteomics datasets from Shorrock et al (UBA1/GARS-dependent pathways drive sensory-motor connectivity defects in spinal muscular atrophy)
Detailed proteomics data files from Shorrock et al., 2018 'UBA1/GARS-dependent pathways drive sensory-motor connectivity defects in spinal muscular atrophy' (Accepted manuscript to be published in Brain).
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