Centre for Discovery Brain Sciences
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The centre carries our research on fundamental physiological mechanisms and pathways, from single genes to complex behaviour, relevant to normal human function and how disruption of these mechanisms lead to disease.
Centre for Discovery Brain Sciences
Image: CC-BY Jones RA, Gillingwater TH https://doi.org/10.7488/ds/1490
Sub-communities within this community
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Richard Ribchester Research Group
Neuromuscular connections
Collections in this community
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Davies Laboratory
Prof Jamie Davies' research on developmental biology -
Gillingwater Laboratory
Neuroscience -
Nolan Lab
Data from the lab of Prof Matt Nolan -
Rochefort Lab
Data associated with publications from the Rochefort Lab -
Spires-Jones Laboratory
Degenerative brain diseases and ageing -
UK Dementia Research Institute
UK DRI at the University of Edinburgh
Recent Submissions
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Introducing blood flow in kidney explants by engraftment onto the chick chorioallantoic membrane is not sufficient to induce arterial smooth muscle cell development
Kidney explant cultures are an important tool to gain insights into developmental processes, insights that can be used to develop strategies for engineering kidneys from stem cells. However, explants are not connected to ... -
MAPseq FASTQ sequences and barcode count matrix Tsoi et al., 2022
Tsoi, Sau Yee, Merve Oncul, Ella Svahn, Mark Robertson, Zuzanna Bogdanowicz, Christina McClure, and Gulsen Surmeli. 2022. “Telencephalic Outputs from the Medial Entorhinal Cortex Are Copied Directly to the Hippocampus.” ... -
Whose behavior? Ca2+ imaging in medial prefrontal cortex during social dominance interactions in a Tube-Test
The study of social dominance interactions between animals offers a window onto the decision-making involved in establishing dominance hierarchies and an opportunity to examine changes in social behavior observed in certain ... -
Human iPSC-derived renal organoids engineered to report oxidative stress can predict drug-induced nephrotoxicity
Advances in regenerative medicine have led to the construction of many types of organoids, which reproduce important aspects of endogenous organs but may be limited or disorganised in nature. While their usefulness for ... -
Data from paper: Reducing voltage-dependent potassium channel Kv3.4 levels ameliorates synapse loss in a mouse model of Alzheimer’s disease
Synapse loss is associated with cognitive decline in Alzheimer’s disease (AD) and owing to their plastic nature, synapses are an ideal target for therapeutic intervention. Oligomeric amyloid beta (Abeta) around amyloid ... -
Macropinocyosis filopodia
Avi movie showing activity-dependent filopodia formation (measured using GPI-GFP) co-incident with SV exocytosis (measured using syp-mOr2). -
Neocortex saves energy by reducing coding precision during food scarcity
Information processing is energetically expensive. In the mammalian brain, it is unclear how information coding and energy use are regulated during food scarcity. Using whole-cell recordings and two-photon imaging in layer ... -
Prenatal anatomical and molecular changes in a mouse model of Spinal Muscular Atrophy: thesis movies
Supplementary movies for the doctoral thesis 'Prenatal anatomical and molecular changes in a mouse model of Spinal Muscular Atrophy'. The movies illustrate the anatomical characterisation performed on embryos of a mouse ... -
Experiential modulation of social dominance in a SYNGAP1 rat model of ASD
Data in support of the article entitled Experiential modulation of social dominance in a SYNGAP1 rat model of ASD in the European Journal of Neuroscience Advances in our understanding of developmental brain disorders such ... -
Inhibitory synapse loss and accumulation of amyloid beta in inhibitory presynaptic terminals in Alzheimer’s disease - Kurucu et al
# Background # Synapse degeneration in Alzheimer’s disease (AD) correlates strongly with cognitive decline. There is well-established excitatory synapse loss in Alzheimer’s disease with known contributions of pathological ... -
SUPERSEDED - Whose behaviour? Ca2+ imaging in medial prefrontal cortex during social dominance interactions in a Tube-Test
## This item has been replaced by the one which can be found at https://doi.org/10.7488/ds/3415 # This data set is a supplement for the article entitled "Whose behaviour? Ca2+ imaging in medial prefrontal cortex during ... -
High and asymmetric somato-dendritic coupling of V1 layer 5 neurons independent of visual stimulation and locomotion
Ex vivo calibration of GCaMP6s and GCaMP6f signals in soma and apical tuft dendrites of layer 5 pyramidal neurons from the mouse primary visual cortex (V1). We examined the relationship between neuronal spiking and calcium ... -
Grid cells are modulated by local head direction
In vivo tetrode recordings from the medial entorhinal cortex of mice during open field exploration. This data set contains recordings from grid cells, conjunctive cells and other spatial cells. Please look at Gerlei_et_a ... -
APP NL/F - 1 year rodent EEG and video recordings. Cerebellum reference. Donepezil administration
This dataset relates to the rodent data reported in the manuscript "Circadian and brain state modulation of network hyperexcitability in Alzheimer's disease". (Brown et al., (2018) 27 April 2018, 5 (2) ENEURO.0426-17.2018. ... -
APP NL/F - 1 year rodent EEG and video recordings. Cortex reference
This dataset relates to the rodent data reported in the manuscript "Circadian and brain state modulation of network hyperexcitability in Alzheimer's disease". (Brown et al., (2018) 27 April 2018, 5 (2) ENEURO.0426-17.2018. ... -
J20 rodent EEG and video recordings
This dataset relates to the rodent data reported in the manuscript "Circadian and brain state modulation of network hyperexcitability in Alzheimer's disease". (Brown et al., (2018) 27 April 2018, 5 (2) ENEURO.0426-17.2018. ... -
APP NL/F - 1 year rodent EEG and video recordings. Cerebellum reference
This dataset relates to the rodent data reported in the manuscript "Circadian and brain state modulation of network hyperexcitability in Alzheimer's disease". (Brown et al., (2018) 27 April 2018, 5 (2) ENEURO.0426-17.2018. ... -
APP NL/F - 8 month rodent EEG and video recordings
This dataset relates to the rodent data reported in the manuscript "Circadian and brain state modulation of network hyperexcitability in Alzheimer's disease". (Brown et al., (2018) 27 April 2018, 5 (2) ENEURO.0426-17.2018. ... -
Motyl AAL, et al. (2020). Pre-symptomatic developmental phenotypes in Spinal Muscular Atrophy
Spinal muscular atrophy (SMA) is a leading genetic cause of infant death, characterised primarily by a loss of lower motor neurons. SMA is caused by mutations in the survival motor neuron 1 (SMN1) gene. New SMN-restoring ... -
Inter- and intra-animal variation in the integrative properties of stellate cells in the medial entorhinal cortex
The data are whole-cell patch-clamp recordings from neurons in the medial entorhinal cortex of adult mice. The data for each neuron is a series of voltage responses to current steps or ramps injected through the recording ...
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