Browsing Centre for Discovery Brain Sciences by Date Accessioned
Now showing items 1-20 of 60
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SUPERSEDED: NMJ-morph
Please see the updated NMJ-morph at http://datashare.is.ed.ac.uk/handle/10283/1907 . NMJ-morph is an ImageJ-based package for morphometric analysis of the neuromuscular junction (NMJ). -
Carboxy Terminus Heat shock Protein 70 interacting Protein reduces tau-associated degenerative changes
One of the hallmarks of Alzheimer’s Disease is the formation of Neurofibrillary Tangles (NFTs), intracellular aggregates of hyperphosphorylated, mislocalized tau protein, which are associated with neuronal loss. Changes ... -
Array Tomography Movie
Video of array tomography procedure with brain tissue carried out as part of the research described in Kay et al http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712649/ . -
Figure 1 Gordon et al (2016) A fine balance of synaptophysin levels underlies efficient retrieval of synaptobrevin II to synaptic vesicles (PLOS ONE)
Data for Gordon et al (2016) PLoS One - "A fine balance of synaptophysin levels underlies efficient retrieval of synaptobrevin II to synaptic vesicles". * Figure 1 – TIFFs displaying fluorescent images after immunostaining ... -
Figures 2/3 Gordon et al (2016) A fine balance of synaptophysin levels underlies efficient retrieval of synaptobrevin II to synaptic vesicles (PLOS ONE)
Data for Gordon et al (2016) PLoS One - "A fine balance of synaptophysin levels underlies efficient retrieval of synaptobrevin II to synaptic vesicles". * Figures 2 and 3 – TIFF stacks displaying the synaptobrevin ... -
Figure 4 Gordon et al (2016) A fine balance of synaptophysin levels underlies efficient retrieval of synaptobrevin II to synaptic vesicles (PLOS ONE)
Data for Gordon et al (2016) PLoS One - "A fine balance of synaptophysin levels underlies efficient retrieval of synaptobrevin II to synaptic vesicles". * Figure 4 - TIFF stacks displaying the synaptobrevin II-pHluorin ... -
SUPERSEDED: NMJ-morph
Please see the updated NMJ-morph at https://doi.org/10.7488/ds/1490 . NMJ-morph is an ImageJ-based package for morphometric analysis of the neuromuscular junction (NMJ). -
Post-mortem brain analyses of the Lothian Birth Cohort 1936: Extending lifetime cognitive and brain phenotyping to the level of the synapse: Data set from publication Henstridge et al 2015 Acta Neuropath Comms
Non-pathological, age-related cognitive decline varies markedly between individuals and places significant financial and emotional strain on people, their families and society as a whole. Understanding the differential ... -
Non-fibrillar oligomeric amyloid-β within synapses: Data set from publication Pickett et al 2016 J Alz Dis
Alzheimer’s disease (AD) is characterized by memory loss, insidious cognitive decline, profound neurodegeneration and the extracellular accumulation of amyloid-beta (Ab) peptide in senile plaques and intracellular accumulation ... -
NMJ-morph
NMJ-morph is an ImageJ-based package for morphometric analysis of the neuromuscular junction (NMJ). -
Human tau increases amyloid beta plaque size but not amyloid beta-mediated synapse loss in a novel mouse model of Alzheimer’s disease: Data set from Jackson et al 2016 EJN
Alzheimer’s disease is characterized by the presence of aggregates of amyloid beta (Aβ) in senile plaques and tau in neurofibrillary tangles, as well as marked neuron and synapse loss. Of these pathological changes, synapse ... -
Data supporting Martin et al (2017) "Symmetry-breaking in branching epithelia..."
These are raw image datasets and analyses used in a J. Anat. paper (Martin et al., 2017) with the following abstract: Branching morphogenesis of epithelia involves division of cells into leader (tip) and follower (stalk) ... -
Spread of tau down neural circuits precedes synapse and neuronal loss in the rTgTauEC mouse model of early Alzheimer’s disease - Data from 2017 Publication
This is the raw data associated with the manuscript Pickett et al (2017) Synapse. We provide the raw images and analysis files. Due to University of Edinburgh DataShare space constraints, we cannot upload the processed ... -
SUPERSEDED - Data supporting Cachat et al. (2017): "Synthetic self-patterning and morphogenesis in mammalian cells: a proof-of-concept step towards synthetic tissue development"
These are raw image datasets used in a manuscript (Cachat et al., 2017: Synthetic self-patterning and morphogenesis in mammalian cells: a proof-of-concept step towards synthetic tissue development) with the following ... -
Data supporting Cachat et al. (2017): "Synthetic self-patterning and morphogenesis in mammalian cells: a proof-of-concept step towards synthetic tissue development"
These are raw image datasets used in a manuscript (Cachat et al., 2017: Synthetic self-patterning and morphogenesis in mammalian cells: a proof-of-concept step towards synthetic tissue development) with the following ... -
Segmentation of the 4DL Connectome 10: CFP 14.3.11-1L
Connectomic analysis of the nervous system aims to discover and establish principles that underpin normal and abnormal neural connectivity and function. In Hirst et al (2013) we performed image analysis of motor unit ... -
Segmentation of the 4DL Connectome 11: CFP 14.3.11-2R
Connectomic analysis of the nervous system aims to discover and establish principles that underpin normal and abnormal neural connectivity and function. In Hirst et al (2013) we performed image analysis of motor unit ... -
Segmentation of the 4DL Connectome 1: Data analysis
Connectomic analysis of the nervous system aims to discover and establish principles that underpin normal and abnormal neural connectivity and function. In Hirst et al (2013) we performed image analysis of motor unit ... -
Segmentation of the 4DL Connectome 12: Deconvolution PSFs (calibration information)
Connectomic analysis of the nervous system aims to discover and establish principles that underpin normal and abnormal neural connectivity and function. In Hirst et al (2013) we performed image analysis of motor unit ... -
Segmentation of the 4DL Connectome 8: YFP-16, 13.9 (incomplete)
Connectomic analysis of the nervous system aims to discover and establish principles that underpin normal and abnormal neural connectivity and function. In Hirst et al (2013) we performed image analysis of motor unit ...
