Browsing Centre for Discovery Brain Sciences by Title
Now showing items 1-20 of 71
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aNMJ-morph macro
It is recommended that users of the aNMJ-morph macro are familiar with the original NMJ-morph workflow in a practical setting; please refer to the following publication for background details: "NMJ-morph reveals principal ... -
APP NL/F - 1 year rodent EEG and video recordings. Cerebellum reference
This dataset relates to the rodent data reported in the manuscript "Circadian and brain state modulation of network hyperexcitability in Alzheimer's disease". (Brown et al., (2018) 27 April 2018, 5 (2) ENEURO.0426-17.2018. ... -
APP NL/F - 1 year rodent EEG and video recordings. Cerebellum reference. Donepezil administration
This dataset relates to the rodent data reported in the manuscript "Circadian and brain state modulation of network hyperexcitability in Alzheimer's disease". (Brown et al., (2018) 27 April 2018, 5 (2) ENEURO.0426-17.2018. ... -
APP NL/F - 1 year rodent EEG and video recordings. Cortex reference
This dataset relates to the rodent data reported in the manuscript "Circadian and brain state modulation of network hyperexcitability in Alzheimer's disease". (Brown et al., (2018) 27 April 2018, 5 (2) ENEURO.0426-17.2018. ... -
APP NL/F - 8 month rodent EEG and video recordings
This dataset relates to the rodent data reported in the manuscript "Circadian and brain state modulation of network hyperexcitability in Alzheimer's disease". (Brown et al., (2018) 27 April 2018, 5 (2) ENEURO.0426-17.2018. ... -
Array Tomography Movie
Video of array tomography procedure with brain tissue carried out as part of the research described in Kay et al http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712649/ . -
Brain Network Measures and Spatial Lesion Distribution in a Sample of 47 Patients with Systemic Lupus Erythematosus (SLE)
This dataset corresponds to a research on network organisation of brain structural connectivity in systemic lupus erythematosus (SLE) and its putative association with lesion distribution and disease indicators. White ... -
Carboxy Terminus Heat shock Protein 70 interacting Protein reduces tau-associated degenerative changes
One of the hallmarks of Alzheimer’s Disease is the formation of Neurofibrillary Tangles (NFTs), intracellular aggregates of hyperphosphorylated, mislocalized tau protein, which are associated with neuronal loss. Changes ... -
Circadian and brain state modulation of network hyperexcitability in Alzheimer's disease - rodent datasets
Network hyperexcitability is a feature of Alzheimer's disease (AD) as well as numerous transgenic mouse models of AD. While hyperexcitability in AD patients and AD animal models share certain features, the mechanistic ... -
Data from paper: Reducing voltage-dependent potassium channel Kv3.4 levels ameliorates synapse loss in a mouse model of Alzheimer’s disease
Synapse loss is associated with cognitive decline in Alzheimer’s disease (AD) and owing to their plastic nature, synapses are an ideal target for therapeutic intervention. Oligomeric amyloid beta (Abeta) around amyloid ... -
Data supporting Cachat et al. (2017): "Synthetic self-patterning and morphogenesis in mammalian cells: a proof-of-concept step towards synthetic tissue development"
These are raw image datasets used in a manuscript (Cachat et al., 2017: Synthetic self-patterning and morphogenesis in mammalian cells: a proof-of-concept step towards synthetic tissue development) with the following ... -
Data supporting Martin et al (2017) "Symmetry-breaking in branching epithelia..."
These are raw image datasets and analyses used in a J. Anat. paper (Martin et al., 2017) with the following abstract: Branching morphogenesis of epithelia involves division of cells into leader (tip) and follower (stalk) ... -
Experiential modulation of social dominance in a SYNGAP1 rat model of ASD
Data in support of the article entitled Experiential modulation of social dominance in a SYNGAP1 rat model of ASD in the European Journal of Neuroscience Advances in our understanding of developmental brain disorders such ... -
Fan cells in layer 2 of lateral entorhinal cortex are critical for episodic-like memory
Episodic memory requires different types of information to be bound together to generate representations of experiences. The lateral entorhinal cortex (LEC) and hippocampus are required for episodic-like memory in rodents. ... -
Figure 1 Gordon et al (2016) A fine balance of synaptophysin levels underlies efficient retrieval of synaptobrevin II to synaptic vesicles (PLOS ONE)
Data for Gordon et al (2016) PLoS One - "A fine balance of synaptophysin levels underlies efficient retrieval of synaptobrevin II to synaptic vesicles". * Figure 1 – TIFFs displaying fluorescent images after immunostaining ... -
Figure 4 Gordon et al (2016) A fine balance of synaptophysin levels underlies efficient retrieval of synaptobrevin II to synaptic vesicles (PLOS ONE)
Data for Gordon et al (2016) PLoS One - "A fine balance of synaptophysin levels underlies efficient retrieval of synaptobrevin II to synaptic vesicles". * Figure 4 - TIFF stacks displaying the synaptobrevin II-pHluorin ... -
Figures 2/3 Gordon et al (2016) A fine balance of synaptophysin levels underlies efficient retrieval of synaptobrevin II to synaptic vesicles (PLOS ONE)
Data for Gordon et al (2016) PLoS One - "A fine balance of synaptophysin levels underlies efficient retrieval of synaptobrevin II to synaptic vesicles". * Figures 2 and 3 – TIFF stacks displaying the synaptobrevin ... -
Grid cells are modulated by local head direction
In vivo tetrode recordings from the medial entorhinal cortex of mice during open field exploration. This data set contains recordings from grid cells, conjunctive cells and other spatial cells. Please look at Gerlei_et_a ... -
High and asymmetric somato-dendritic coupling of V1 layer 5 neurons independent of visual stimulation and locomotion
Ex vivo calibration of GCaMP6s and GCaMP6f signals in soma and apical tuft dendrites of layer 5 pyramidal neurons from the mouse primary visual cortex (V1). We examined the relationship between neuronal spiking and calcium ... -
Human iPSC-derived renal organoids engineered to report oxidative stress can predict drug-induced nephrotoxicity
Advances in regenerative medicine have led to the construction of many types of organoids, which reproduce important aspects of endogenous organs but may be limited or disorganised in nature. While their usefulness for ...
