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Spread of tau down neural circuits precedes synapse and neuronal loss in the rTgTauEC mouse model of early Alzheimer’s disease - Data from 2017 Publication
This is the raw data associated with the manuscript Pickett et al (2017) Synapse. We provide the raw images and analysis files. Due to University of Edinburgh DataShare space constraints, we cannot upload the processed ...
Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis - Analysis macros
In addition to motor neurone degeneration, up to 50% of Amyotrophic Lateral Sclerosis (ALS) patients present with cognitive decline. Understanding the neurobiological changes underlying these cognitive deficits is critical, ...
An Investigation of Synaptic Dysfunction in Alzheimer’s Disease - Chapter 6 - Image J Macros
Alzheimer’s disease (AD) is characterized by the presence of aggregates of amyloid beta (Aβ) in senile plaques and tau in neurofibrillary tangles, as well as marked neuron and synapse loss. Of these pathological changes, ...
aNMJ-morph macro
It is recommended that users of the aNMJ-morph macro are familiar with the original NMJ-morph workflow in a practical setting; please refer to the following publication for background details: "NMJ-morph reveals principal ...
NMJ-morph
NMJ-morph is an ImageJ-based package for morphometric analysis of the neuromuscular junction (NMJ).
Array Tomography Movie
Video of array tomography procedure with brain tissue carried out as part of the research described in Kay et al http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712649/ .
SUPERSEDED: NMJ-morph
Please see the updated NMJ-morph at https://doi.org/10.7488/ds/1490 . NMJ-morph is an ImageJ-based package for morphometric analysis of the neuromuscular junction (NMJ).
Systematic Review of the Literature on Definitions and Characterisation of MS Lesions
While inspecting the brain magnetic resonance imaging (MRI) scans from a sample of Multiple Sclerosis (MS) patients, blind to any clinical, cognitive and demographic information, it caught our attention the presence of ...
SUPERSEDED - Supplementary Figures: Interleukin-1 receptor antagonist treatment in acute ischaemic stroke does not alter systemic markers of anti-microbial defence
## This item has been replaced by the one which can be found at https://doi.org/10.7488/ds/2626 ## Supplementary Figures from the manuscript "Interleukin-1 receptor antagonist treatment in acute ischaemic stroke does not ...
An Investigation of Synaptic Dysfunction in Alzheimer’s Disease - Chapter 3 - Thresholding Macros
Alzheimer’s disease (AD) is characterized by the presence of aggregates of amyloid beta (Aβ) in senile plaques and tau in neurofibrillary tangles, as well as marked neuron and synapse loss. Of these pathological changes, ...
An Investigation of Synaptic Dysfunction in Alzheimer’s Disease - Chapter 5 - Thresholding Macros
Alzheimer’s disease (AD) is characterized by the presence of aggregates of amyloid beta (Aβ) in senile plaques and tau in neurofibrillary tangles, as well as marked neuron and synapse loss. Of these pathological changes, ...
SUPERSEDED: NMJ-morph
Please see the updated NMJ-morph at https://doi.org/10.7488/ds/1490 . NMJ-morph is an ImageJ-based package for morphometric analysis of the neuromuscular junction (NMJ).
An Investigation of Synaptic Dysfunction in Alzheimer’s Disease - Chapter 3 - Matlab Scripts
Alzheimer’s disease (AD) is characterized by the presence of aggregates of amyloid beta (Aβ) in senile plaques and tau in neurofibrillary tangles, as well as marked neuron and synapse loss. Of these pathological changes, ...
Region-specific depletion of synaptic mitochondria in the brains of patients with Alzheimer's disease - TEM data
Of all of the neuropathological changes observed in Alzheimer's disease (AD), the loss of synapses correlates most strongly with cognitive decline. The precise mechanisms of synapse degeneration in AD remain unclear, ...
Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis - Array tomography data
We provide the raw array tomography data that was analysed for the publication "Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis", published in Acta Neuropathologica ...
Interleukin-1 receptor antagonist treatment in acute ischaemic stroke does not alter systemic markers of anti-microbial defence
Background: Blockade of the cytokine interleukin-1 (IL-1) with IL-1 receptor antagonist (IL-1Ra) is a candidate treatment for stroke entering phase II/III trials, which acts by inhibiting harmful inflammatory responses. ...
SUPERSEDED - Interleukin-1 receptor antagonist treatment in acute ischaemic stroke does not alter systemic markers of anti-microbial defence
## This item has been replaced by the one which can be found at https://doi.org/10.7488/ds/2626 ## Background: Blockade of the cytokine interleukin-1 (IL-1) with IL-1 receptor antagonist (IL-1Ra) is a candidate treatment ...
An Investigation of Synaptic Dysfunction in Alzheimer’s Disease - Chapter 5 - Matlab Scripts
Alzheimer’s disease (AD) is characterized by the presence of aggregates of amyloid beta (Aβ) in senile plaques and tau in neurofibrillary tangles, as well as marked neuron and synapse loss. Of these pathological changes, ...
An Investigation of Synaptic Dysfunction in Alzheimer’s Disease - Chapter 6 - Cell Profiler Pipeline
Alzheimer’s disease (AD) is characterized by the presence of aggregates of amyloid beta (Aβ) in senile plaques and tau in neurofibrillary tangles, as well as marked neuron and synapse loss. Of these pathological changes, ...
SUPERSEDED - Interleukin-1 receptor antagonist treatment in acute ischaemic stroke does not alter systemic markers of anti-microbial defence
## This item has been replaced by the one which can be found at http://hdl.handle.net/10283/3354 ## Full datasets for all figures in the manuscript "Interleukin-1 receptor antagonist treatment in acute ischaemic stroke ...
