Now showing items 1-19 of 19
Spread of tau down neural circuits precedes synapse and neuronal loss in the rTgTauEC mouse model of early Alzheimer’s disease - Data from 2017 Publication
This is the raw data associated with the manuscript Pickett et al (2017) Synapse. We provide the raw images and analysis files. Due to University of Edinburgh DataShare space constraints, we cannot upload the processed ...
Segmentation of the 4DL Connectome 10: CFP 14.3.11-1L
Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis - Analysis macros
In addition to motor neurone degeneration, up to 50% of Amyotrophic Lateral Sclerosis (ALS) patients present with cognitive decline. Understanding the neurobiological changes underlying these cognitive deficits is critical, ...
Segmentation of the 4DL Connectome 12: Deconvolution PSFs (calibration information)
Segmentation of the 4DL Connectome 1: Data analysis
Segmentation of the 4DL Connectome 5: YFP-16, 19.11-1L – primary images and endplate analysis
Research Plan - The effect of APOE genotype on microglial-mediated synapse loss in AD
This is a pre-registration of an experimental plan to examine the effect of APOE genotype on microglial-mediated synapse loss in Alzheimer's disease. There is now extensive literature covering synapse loss in AD and mouse ...
Segmentation of the 4DL Connectome 9: YFP-16, 21.9-2L (incomplete)
Segmentation of the 4DL Connectome 7: YFP-16, 19.11-1R
Segmentation of the 4DL Connectome 11: CFP 14.3.11-2R
Segmentation of the 4DL Connectome 8: YFP-16, 13.9 (incomplete)
Segmentation of the 4DL Connectome 6: YFP-16, 19.11-1L – axon segmentation
Segmentation of the 4DL Connectome 4: YFP-16, 19.8
Connectomic analysis of the nervous system aims to discover and establish principles that underpin normal and abnormal neural connectivity and function. In Hirst et al (2013) the data creators performed image analysis of ...
Region-specific depletion of synaptic mitochondria in the brains of patients with Alzheimer's disease - TEM data
Of all of the neuropathological changes observed in Alzheimer's disease (AD), the loss of synapses correlates most strongly with cognitive decline. The precise mechanisms of synapse degeneration in AD remain unclear, ...
Segmentation of the 4DL Connectome 2: YFP-H 1.3-19.3
Segmentation of the 4DL Connectome 3: YFP-H 9.6
Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis - Array tomography data
We provide the raw array tomography data that was analysed for the publication "Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis", published in Acta Neuropathologica ...
Non-fibrillar oligomeric amyloid-β within synapses: Data set from publication Pickett et al 2016 J Alz Dis
Alzheimer’s disease (AD) is characterized by memory loss, insidious cognitive decline, profound neurodegeneration and the extracellular accumulation of amyloid-beta (Ab) peptide in senile plaques and intracellular accumulation ...
Human tau increases amyloid beta plaque size but not amyloid beta-mediated synapse loss in a novel mouse model of Alzheimer’s disease: Data set from Jackson et al 2016 EJN
Alzheimer’s disease is characterized by the presence of aggregates of amyloid beta (Aβ) in senile plaques and tau in neurofibrillary tangles, as well as marked neuron and synapse loss. Of these pathological changes, synapse ...