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Pervasive lesion segregation shapes cancer genome evolution

Aitken, Sarah; Anderson, Craig; Frances, Connor; Rayner, Tim; Lukk, Margus; Feng, Christine; Semple, Colin; Lopez-Bigas, Nuria; Flicek, Paul; Odom, Duncan; Taylor, Martin

Cancers arise through the acquisition of oncogenic mutations and grow by clonal expansion. Here we reveal that most mutagenic DNA lesions are not resolved into a mutated DNA base pair within a single cell cycle. Instead, ...