Quantitative Trait Locus (QTL) Identification
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The aims of this work are (i) to genetically map and identify quantitative trait loci (QTL) concerned with common human disorders; (ii) to characterise the genetic architecture of complex traits; (iii) to evaluate the use of genetic markers in trait prediction and treatment.
Items in this Collection
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Additional Data pertaining to publication: Meta-GWAS Reveals Novel Genetic Variants Associated with Urinary Excretion of Uromodulin
Additional Data pertaining to publication: Meta-GWAS Reveals Novel Genetic Variants Associated with Urinary Excretion of Uromodulin Uromodulin, the most abundant protein excreted in normal urine, plays major roles in ... -
GWAS summary statistics pertaining to the publication "Genetic regulation of post-translational modification of two distinct proteins"
Post-translational modifications diversify protein functions and dynamically coordinate their signalling networks, influencing most aspects of cell physiology. Nevertheless, their genetic regulation or influence on complex ... -
SUPERSEDED - GWAS summary statistics pertaining to the publication "Same role but different actors: genetic regulation of post-translational modification of two distinct proteins"
## This item has been replaced by the one which can be found at https://datashare.ed.ac.uk/handle/10283/4088 ## Post-translational modifications (PTMs) diversify protein functions and dynamically coordinate their signalling ... -
Supplementary Tables for David W Clark's PhD Thesis "Inbreeding depression on human complex traits"
Appendix tables from the doctoral thesis of David W Clark "Inbreeding depression on human complex traits". -
Traveller Genes Data Dictionary
Traveller Genes is a research study supported by the Traveller community. We're looking at the genetics, origins and health of over 200 volunteers who have at least two grandparents who are or were Travellers. This includes ... -
Viking II Data Dictionary
VIKING II was made possible thanks to Medical Research Council (MRC) funding. We aim to better understand what might cause diseases such as heart disease, eye disease, stroke, diabetes and others by inviting 4,000 people ... -
Extended Supplementary Tables for Thesis: "Omics Measures of Ageing and Disease Susceptibility" by Erin Macdonald-Dunlop
Extended supplementary tables from the thesis entitled "Omics Measures of Ageing and Disease Susceptibility" by Erin Macdonald-Dunlop. Supplementary tables for the three results chapters are in the corresponding ... -
Data pertaining to publication: Meta-GWAS Reveals Novel Genetic Variants Associated with Urinary Excretion of Uromodulin
Uromodulin, the most abundant protein excreted in normal urine, plays major roles in kidney physiology and disease. The mechanisms regulating the urinary excretion of uromodulin remain essentially unknown. We conducted a ... -
GWAMA summary data for morning plasma cortisol from the Cortisol Network (CORNET) Consortium 2021 (n=25,314)
The stress hormone cortisol modulates fuel metabolism, cardiovascular homoeostasis, mood, inflammation and cognition. The CORtisol NETwork (CORNET) consortium previously identified a single locus associated with morning ... -
Mendelian randomization of genetically independent aging phenotypes identifies LPA and VCAM1 as biological targets for human aging
Genome-wide association summary statistics supporting the article Timmers et. al (2022) Nature Aging https://doi.org/10.1038/s43587-021-00159-8. -
Cornea resistance factor GWAS in the UK Biobank
Summary statistics from the genome-wide association study (GWAS) of cornea resistance factor (CRF) of 76,029 UK Biobank samples of British ancestry obtained through the application number 19655. The CRF analysis was ... -
Protein genome-wide associations from the paper 'Linking protein to phenotype with Mendelian Randomization detects 38 proteins with causal roles in human diseases and traits'.
Data in support of the manuscript "Linking protein to phenotype with Mendelian Randomization detects 38 proteins with causal roles in human diseases and traits". -
Insights into the genetic basis of retinal detachment
Dataset of genome-wide association meta-analysis summary statistics associated with the publication “Insights into the genetic basis of retinal detachment” available at HMG: DOI: 10.1093/hmg/ddz294. If you use this dataset, ... -
Dataset 2 pertaining to the publication "Exploration of haplotype research consortium imputation for genome-wide association studies in 20,032 Generation Scotland participants"
The Generation Scotland: Scottish Family Health Study (GS:SFHS) is a family-based population cohort with DNA, biological samples, socio-demographic, psychological and clinical data from ~24,000 adult volunteers across ... -
GWAS summary statistics for UPLC IgG N-glycosylation traits
The majority of proteins undergo post-translational glycosylation, in which complex carbohydrates are attached to the surface of proteins. However, when studying glycoproteins, the glycan component is often neglected. ... -
Dataset concerning the manuscript "Rare variants implicate ENPP6 as a regulator of reduced visceral adiposity"
The Orkney Complex Disease Study (ORCADES) is a family-based population cohort with DNA, biological samples, and a wide range of clinical data from ~2,000 adult volunteers from the Orkney Islands. Genotype data is also ... -
Central cornea thickness Genome Wide Association Meta Analyses - Summary statistics
Results from the meta-analyses of genome-wide association studies for central cornea thickness in human. Corneal thinning is a common feature of rare Mendelian connective tissue disorders, such as Ehlers-Danlos syndrome ... -
GWAS summary statistics for uric acid in GS:SFHS
The Generation Scotland: Scottish Family Health Study (GS:SFHS) is a family-based population cohort with DNA, biological samples, socio-demographic, psychological and clinical data from ~24,000 adult volunteers across ... -
SUPERSEDED - Summary GWAS data for morning plasma cortisol from the Cortisol Network (CORNET) Consortium 2014 (n=12,597)
## This Item has been replaced by the one which can be found at https://doi.org/10.7488/ds/2986 . ## Variation in plasma levels of cortisol, an essential hormone in the stress response, is associated in population-based ... -
Dataset 1 pertaining to the publication "Exploration of haplotype research consortium imputation for genome-wide association studies in 20,032 Generation Scotland participants"
The Generation Scotland: Scottish Family Health Study (GS:SFHS) is a family-based population cohort with DNA, biological samples, socio-demographic, psychological and clinical data from ~24,000 adult volunteers across ...
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