Nolan Lab
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Data associated with publications from the Nolan Lab.
The lab's researchers are interested in molecular mechanisms that configure neural circuits to carry out computations. The approach taken combines electrophysiological, molecular and behavioural analysis, with computational modelling and development of molecular and software tools. The hope is that over the long term this research will be important for understanding and treating clinical disorders such as Alzheimer’s, schizophrenia, autism and epilepsy.
Items in this Collection
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Anatomical substrates for local connectivity of neurons in layers 5a and 5b of the medial entorhinal cortex
Data used to generate figures and statistical outputs for the upcoming publication Christina M. Brown, Saishree Badrinarayanan, Zuohang Wu, Martyna Rakowska, Derek L. F. Garden, Matthew F. Nolan (in submission). 'Anatomical ... -
Fan cells in lateral entorhinal cortex directly influence medial entorhinal cortex through synaptic connections in layer 1
Data used to generate figures and statistical outputs for https://www.biorxiv.org/content/10.1101/2022.08.25.505296v1. Analysis code used for this dataset can be found at https://github.com/MattNolanLab/lec_to_mec. # ... -
Spatial representation by ramping activity of neurons in the retrohippocampal cortex
The dataset is from an investigation of activity of neurons in the retrohippocampal cortices during recall of a spatial memory. During the experiment mice carry out a task in a virtual reality environment in which they ... -
Single photon kilohertz frame rate imaging of neural activity
Establishing the biological basis of cognition and its disorders will require high precision spatiotemporal measurements of neural activity. Recently developed genetically encoded voltage indicators (GEVIs) report both ... -
Grid cells are modulated by local head direction
In vivo tetrode recordings from the medial entorhinal cortex of mice during open field exploration. This data set contains recordings from grid cells, conjunctive cells and other spatial cells. Please look at Gerlei_et_a ... -
Inter- and intra-animal variation in the integrative properties of stellate cells in the medial entorhinal cortex
The data are whole-cell patch-clamp recordings from neurons in the medial entorhinal cortex of adult mice. The data for each neuron is a series of voltage responses to current steps or ramps injected through the recording ... -
Fan cells in layer 2 of lateral entorhinal cortex are critical for episodic-like memory
Episodic memory requires different types of information to be bound together to generate representations of experiences. The lateral entorhinal cortex (LEC) and hippocampus are required for episodic-like memory in rodents. ... -
Stellate cells in medial entorhinal cortex are required for spatial learning
Spatial learning requires estimates of location that may be obtained by path integration or from positional cues. Grid and other spatial firing patterns of neurons in the superficial medial entorhinal cortex (MEC) suggest ...
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