Centre for Genomic & Experimental Medicine (CGEM)

 

The mission of the Centre for Genomic and Experimental Medicine is to use genetics and genomics to understand the mechanisms of disease and inform novel intervention strategies. The centre's researchers undertake detailed studies of populations, families and individuals to study a wide range of health related conditions, using state-of-the-art genetic, epigenetic, genomic, statistical, computational, biological and molecular approaches.

Collections in this community

Recent Submissions

  • cAge and bAge EWAS - Epigenome-wide association study of chronological age (linear and quadratic) and of survival 

    Bernabeu, Elena; McCartney, Daniel L.; Gadd, Danni A.; Hillary, Robert F.; Lu, Ake T.; Murphy, Lee; Wrobel, Nicola; Campbell, Archie; Harris, Sara E.; Liewald, David; Hayward, Caroline; Porteous, David J.; Sudlow, Cathie; Cox, Simon R.; Evans, Kathy L.; Horvath, Steve; McIntosh, Andrew M.; Robinson, Matthew R.; Vallejos, Catalina A.; Marioni, Riccardo E.
    These datasets correspond to the manuscript “Refining epigenetic prediction of chronological and biological age“. Here, we include the summary statistics for an epigenome-wide association study (EWAS) of age, considering ...

  • SUPERSEDED - cAge and bAge EWAS - Epigenome-wide association study of chronological age (linear and quadratic) and of survival 

    McCartney, Daniel L.; Gadd, Danni A.; Hillary, Robert F.; Lu, Ake T.; Murphy, Lee; Wrobel, Nicola; Campbell, Archie; Harris, Sara E.; Liewald, David; Hayward, Caroline; Porteous, David J.; Sudlow, Cathie; Cox, Simon R.; Evans, Kathy L.; Horvath, Steve; McIntosh, Andrew M.; Robinson, Matthew R.; Vallejos, Catalina A.; Marioni, Riccardo E.; Bernabeu, Elena
    ## This deposit has been superseded by the one which can be found at https://doi.org/10.7488/ds/3792 ## These datasets correspond to the manuscript “Refining epigenetic prediction of chronological and biological age“. ...

  • BayesR+ GWAS - Genome and epigenome wide studies of plasma protein biomarkers for Alzheimer's disease implicate TBCA and TREM2 in disease risk 

    Hillary, Robert; Gadd, Danni; McCartney, Daniel; Shi, Liu; Campbell, Archie; Walker, Rosie; Ritchie, Craig; Deary, Ian; Evans, Kathryn; Nevado-Holgado, Alejo; Hayward, Caroline; Porteous, David; McIntosh, Andrew; Lovestone, Simon; Robinson, Matthew; Marioni, Riccardo
    This dataset represents one of two datasets that correspond to the study: "Genome and epigenome wide studies of plasma protein biomarkers for Alzheimer's disease implicate TBCA and TREM2 in disease risk". The datasets ...

  • BayesR+ EWAS - Genome and epigenome wide studies of plasma protein biomarkers for Alzheimer's disease implicate TBCA and TREM2 in disease risk 

    Hillary, Robert; Gadd, Danni; McCartney, Daniel; Shi, Liu; Campbell, Archie; Walker, Rosie; Ritchie, Craig; Deary, Ian; Evans, Kathryn; Nevado-Holgado, Alejo; Hayward, Caroline; Porteous, David; McIntosh, Andrew; Lovestone, Simon; Robinson, Matthew
    This dataset represents one of two datasets that correspond to the study: "Genome and epigenome wide studies of plasma protein biomarkers for Alzheimer's disease implicate TBCA and TREM2 in disease risk". The datasets ...

  • Summary statistics from epigenome-wide association studies and meta-analysis comparing APOE ε4 and APOE ε2 allele carriers in Generation Scotland 

    Walker, Rosie; Vaher, Kadi; Bermingham, Mairead; Morris, Stewart; Bretherick, Andrew; Zeng, Yanni; Rawlik, Konrad; Amador, Carmen; Campbell, Archie; Haley, Chris; Hayward, Caroline; Porteous, David; McIntosh, Andrew; Marioni, Riccardo; Evans, Kathryn
    These datasets contain full summary statistics for epigenome-wide association studies (EWASs) carried out using two methylation samples from the Generation Scotland: Scottish Family Health Study to investigate associations ...

  • Birth weight associations with DNA methylation differences in an adult population 

    Madden, Rebecca A; McCartney, Daniel L; Hillary, Robert F; Bermingham, Mairead L; Rawlik, Konrad; Morris, Stewart W; Campbell, Archie; Porteous, David J; Deary, Ian J; Evans, Kathryn L; Hafferty, Jonathan; McIntosh, Andrew M; Marioni, Riccardo E
    The Developmental Origins Health and Disease (DOHaD) theory predicts that prenatal and early life events shape adult health outcomes. Birth weight is a useful indicator of the foetal experience, and has been associated ...

  • Genome-wide association summary statistics of antidepressant treatment resistance meta-analysis 

    Wigmore, Ella; Hafferty, Jonathan; Hall, Lynsey; Howard, David; Clarke, Toni-Kim; Fabbri, Chiara; Lewis, Cathryn; Uher, Rudolf; Navrady, Lauren; Adams, Mark; Zeng, Yanni; Campbell, Archie; Gibson, Jude; Thomson, Pippa; Hayward, Caroline; Smith, Blair; Hocking, Lynne; Padmanabhan, Sandosh; Deary, Ian; Porteous, David; Mors, Ole; Mattheisen, Manuel; Nicodemus, Kristin; McIntosh, Andrew
    Data from Wigmore et al "Genome-wide association study of antidepressant treatment resistance in a population-based cohort using health service prescription data and meta-analysis with GENDEP". The Pharmacogenomics Journal ...

  • A Celebration of Scottish Health Cohort Studies: Participants' attitudes towards data research 

    Beange, Iona; McIntosh, Andrew; Kirkham, Elizabeth; Fletcher-Watson, Sue; Lawrie, Stephen; Batty, David; Boardman, James; Black, Corri; Porteous, David
    BACKGROUND. The UK hosts many of the world’s longest running prospective longitudinal birth cohort studies. These projects make repeated observations of their participants and use this data to explore health outcomes ...

  • Generation Scotland Age x Sex Epigenome Wide Association Study Summary Statistics 

    McCartney, Daniel; Zhang, Futao; Hillary, Robert; Zhang, Qian; Stevenson, Anna; Walker, Rosie; Bermingham, Mairead; Boutin, Thibaud; Morris, Stewart; Campbell, Archie; Murray, Alison; Whalley, Heather; Porteous, David; Hayward, Caroline; Evans, Kathy; Chandra, Tamir; Deary, Ian; McIntosh, Andrew; Yang, Jian; Visscher, Peter; McRae, Allan; Marioni, Riccardo
    This directory contains full summary statistics for the following EWAS studies in the Generation Scotland cohort. Epigenome-wide autosomal sites associated with chronological age with concordant effect sizes in the ...

  • Generation Scotland Survey Monkey data 

    Edwards, Rachel; Campbell, Archie; Porteous, David
    Generation Scotland (GS) conducted a recontact survey on ~7,000 participants who could be contacted by email. The survey used Survey Monkey Inc. to understand GS participant opinions on health research. A total of 2,316 ...

  • Comparison of DNA methylation profiles from Generation Scotland blood samples stored on Whatman FTA cards and in EDTA tubes: EWAS summary statistics 

    Walker, Rosie; MacGillivray, Louise; McCafferty, Sarah; Wrobel, Nicola; Kerr, Shona; Morris, Stewart; Campbell, Archie; McIntosh, Andrew; Porteous, David; Evans, Kathryn
    This dataset contains summary statistics for the epigenome-wide association studies (EWASs) performed to ascertain the feasibility of profiling DNA methylation using dried blood spot (DBS) DNA from Generation Scotland ...

  • Generation Scotland SFHS Data Dictionary 

    Campbell, Archie; Kerr, Shona; Porteus, David
    The GS:SFHS Data Dictionary is a set of information describing the contents, format, and structure of the phenotype data collected during recruitment (2006-2011) to the Generation Scotland Scottish Family Health Study ...

  • SUPERSEDED - Generation Scotland SFHS Data Dictionary 

    Campbell, Archie; Kerr, Shona; Porteous, David
    ## This item has been replaced by the one which can be found at https://doi.org/10.7488/ds/2277 . ## The GS:SFHS Data Dictionary is a set of information describing the contents, format, and structure of the phenotype data ...

  • Generation Scotland: Donor DNA Databank 

    Kerr, Shona; Porteous, David; Campbell, Archie
    The Generation Scotland Donor DNA Databank (GS:3D) phenotype was collected from consented blood donors by questionnaire and relates to 4,998 healthy control DNA samples and plasma.