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Reference segmentations of white matter hyperintensities from a subset of 20 subjects scanned three consecutive years
This dataset contains structural magnetic resonance imaging (MRI)-derived data from 20 participants enrolled in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) project. These data are probabilistic estimates maps ...
Proteomic profiling of primate synapses during normal healthy ageing
Normal mammalian brain ageing is characterised by the selective loss of discrete populations of dendritic spines and synapses, particularly affecting neuroanatomical regions such as the hippocampus. Although previous ...
Multivariate genomic scan implicates novel loci and haem metabolism in human ageing
Ageing phenotypes, such as years lived in good health (healthspan), total years lived (lifespan), and survival until an exceptional old age (longevity), are of interest to us all but require exceptionally large sample sizes ...
Post-mortem brain analyses of the Lothian Birth Cohort 1936: Extending lifetime cognitive and brain phenotyping to the level of the synapse: Data set from publication Henstridge et al 2015 Acta Neuropath Comms
Non-pathological, age-related cognitive decline varies markedly between individuals and places significant financial and emotional strain on people, their families and society as a whole. Understanding the differential ...
Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances
We use a genome-wide association of 1 million parental lifespans of genotyped subjects and data on mortality risk factors to validate previously unreplicated findings near CDKN2B-AS1, ATXN2/BRAP, FURIN/FES, ZW10, PSORS1C3, ...
Role of accelerated ageing in limb muscle wasting of patients with Chronic Obstructive Pulmonary Disease (COPD)
Skeletal muscle wasting is an independent predictor of health-related quality of life, and survival in COPD, but the complexity of the molecular mechanisms associated with this process have not been fully elucidated. We ...
Synaptic and non synaptic proteome in ageing murine cortical isolates
Label free proteomic analysis of "synaptic" and "non-synaptic" mitochondrial subpopulations isolated from murine cortex throughout the process of "normal healthy" ageing. These are sub populations of mitochondria as ...
Genetically independent phenotype analysis identifies LPA and VCAM1 as drug targets for human ageing
Data supporting the manuscript Timmers et. al (2021) bioRXiv https://doi.org/10.1101/2021.01.22.427837 .
