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Multivariate genomic scan implicates novel loci and haem metabolism in human ageing

Timmers, Paul RHJ; Wilson, James F; Joshi, Peter K; Deelen, Joris

Ageing phenotypes, such as years lived in good health (healthspan), total years lived (lifespan), and survival until an exceptional old age (longevity), are of interest to us all but require exceptionally large sample sizes ...

Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances

Timmers, Paul R H J; Läll, Kristi; Fischer, Krista; Ning, Zheng; Feng, Xiao; Bretherick, Andrew; Clark, David W; Shen, Xia; Esko, Tōnu; Kutalik, Zoltán; Wilson, James F; Joshi, Peter K

We use a genome-wide association of 1 million parental lifespans of genotyped subjects and data on mortality risk factors to validate previously unreplicated findings near CDKN2B-AS1, ATXN2/BRAP, FURIN/FES, ZW10, PSORS1C3, ...